alexa Effect of Vitamin C and Vitamin E on Mercuric Chloride -Induced Reproductive Toxicity in Male Rats | OMICS International | Abstract
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Vitamin C and Vitamin E on Mercuric Chloride -Induced Reproductive Toxicity in Male Rats

Muthu K1 and Krishnamoorthy P2*
1Department of Zoology, Raja Serfoji College, Thanjavur-622 404, Tamil Nadu, India
2Department of Biotechnology, J. J.College of Arts and Science, Pudukottai-622 404, Tamil Nadu, India
Corresponding Author : Krishnamoorthy P
Department of Biotechnology
J. J.College of Arts and Science
Pudukottai-622 404, Tamil Nadu, India
E-mail: [email protected]
Received June 18, 2012; Accepted August 29, 2012; Published August 31, 2012
Citation: Muthu K, Krishnamoorthy P (2012) Effect of Vitamin C and Vitamin E on Mercuric Chloride -Induced Reproductive Toxicity in Male Rats. Biochem Pharmacol 1:102. doi:10.4172/2167-0501.1000102
Copyright: © 2012Muthu K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

To evaluate the protective effects of Vitamin C and Vitamin E against Mercuric chloride -induced reproductive toxicity and to study the mechanisms underlying these effects. Male Wistar rats were orally administered mercuric chloride (10 mg/100 gm b.wt), (10 mg/100 gm b.wt) of mercuric chloride + (40 mg/100 gm b.wt) of Vitamin C and (10 mg/100 gm b.wt) of mercuric chloride + (20 mg/100 gm b.wt) of Vitamin E were administered orally to male albino rats for 30 days. Treatments with either Vitamin C or Vitamin E resulted in a significant protection of reproductive function. Both vitamins reduced the extent of mercuric chloride-induced reproductive toxicity, as evidenced by decrease in sperm abnormality and increase in sperm motility. Mercuric chloride-induced alterations in testis lipid peroxidation (MDA) were also markedly improved by test vitamins, and mercuric chloride -induced alterations in the testis antioxidation defense system were profoundly prevented by vitamins. In groups, where mercuric chloride was combined with either Vitamin C or Vitamin E, antioxidation enzymes like superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) were significantly elevated compared to the mercuric chloride-treated group. The results provide further insight into the mechanisms of mercuric chloride-induced reproductive toxicity and confirm the antioxidant potential of both Vitamin C and Vitamin E.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version