Effect on B Cell Function by Mesenchymal Stem Cells of Different DerivationErin L Collins*, Maosong Qi and Gary Gilkeson
Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
- *Corresponding Author:
- Erin L Collins
Division of Rheumatology and Immunology
Department of Medicine, Medical University of South Carolina, Charleston
SC 29425*, USA
E-mail: [email protected]
Received date: March 04, 2015; Accepted date: July 23, 2015; Published date: July 25, 2015
Citation: Collins EL, Qi M, Gilkeson G (2015) Effect on B Cell Function by Mesenchymal Stem Cells of Different Derivation. J Stem Cell Res Ther 5:294. doi:10.4172/2157-7633.1000294
Copyright: © 2015 Collins EL, et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have broad immunomodulatory properties. The regulatory mechanism of MSCs is of particular relevance due to interests in cell therapy. Although many studies regarding MSC mechanism of action has been reported, MSC effects on B cell proliferation and function is controversial. B cells play an important role in the disease pathogenesis of systemic lupus erythematosus (SLE). If MSCs are to be developed as a cell therapy for lupus it is important to understand the interaction of MSCs and B cells. In this study we revisit and expand studies of MSCs from various sources on healthy and lupus patient CD19+ B cell proliferation and begin to examine the mechanism by which these cells are interacting. Our results clearly indicate that MSCs are able to have significant effects on B cell proliferation and TNFα production. Moreover, MSC do not enhance B cell proliferation or function in vitro.