alexa Effective Size and Effectiveness: Next Generation Seque
ISSN 2469-9853

Journal of Next Generation Sequencing & Applications
Open Access

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Short Communication

Effective Size and Effectiveness: Next Generation Sequencing and the Practice of Genomics in Africa

Muntaser Ibrahim* and Mahmoud Musa
Institute of Endemic Diseases, University of Khartoum, Medical Campus, Khartoum, Sudan
*Corresponding Author : Muntaser Ibrahim
Institute of Endemic Diseases
University of Khartoum, Medical Campus, Khartoum, Sudan
Tel: +249 11 310102
E-mail: [email protected]
Rec date: Oct 29, 2015; Acc date: Feb 26, 2016; Pub date: Feb 29, 2016
Citation: Ibrahim M, Musa M (2016) Effective Size and Effectiveness: Next Generation Sequencing and the Practice of Genomics in Africa. Next Generat Sequenc & Applic S1:008. doi:10.4172/2469-9853.S1-008
Copyright: © 2016 Ibrahim M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




The tremendous and unprecedented insights provided by next generation sequencing into genome functions, variations and interactions promises an enormous shift in our attitude towards individual and population genetics, both in health and disease. Concepts and paradigms could be verified or nullified based on large complete sets of data rather than few genes or inference from large sets of comparison with substantial gaps like genome wide association studies (GWAS). Functional variant(s) may be associated with phenotypes at a “personalized” level. Rare variants underlying common diseases-and even underlying variations in health-are a frequent encounter in the genomic era. Simple inductive generalizations would hastily blur the lines between what is a true abnormality and what is not.

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