Orthopedic & Muscular System: Current Research
Open Access

Abstract

Effectiveness of Celecoxib and Acetaminophen after Anterior Crutiate Ligament Reconstruction

Babak Siavashi, Reza Bahador and Mohammad Javad Zehtab

Aim: To evaluate the analgesic efficacy of administering Celecoxib as a component of multimodal analgesia for patients undergoing anterior cruciate ligament reconstruction surgery.
Methods: We conducted a randomized double blind placebo controlled clinical trial and included all 90 patients who were going to treated with ACL reconstruction in Sina Hospital during 2009-2010. After obtaining written informed consent, we administered Celecoxib 400 mg and Acetaminophen 750 mg 1-2 hours preoperatively to one group (43 patients) and placebo and the same dosage of acetaminophen to the second (47 patients). Postoperatively, all patients received Acetaminophen 750 mg every 6 hours in addition to Celecoxib 200 mg every 12 hours for case group or placebo for controls. This analgesic regimen continued for duration of 2 weeks in which all patients participated in a aggressive rapid rehabilitation program. The patients were evaluated at the end of 2nd week and 6th month. Data analysis performed using SPSS.
Results: Patients of two groups were similar with respect to probable confounder variables such as age, sex, weight, level of activity, side of operated knee and the duration of operation. Patellofemoral complications were observed in 13 and 39 patients of case and control group, respectively. The difference was statistically significant. However, the difference between the rate of observed regional pain syndrome among patients of two groups were not statistically significant.
Conclusion: It seems that using Celecoxib as a component of multimodal analgesia leads to increase patient cooperation in participation to rehabilitation program and finally improve the outcomes.