Effectiveness of Celecoxib and Acetaminophen after Anterior Crutiate Ligament Reconstruction
- *Corresponding Author:
- Dr. Babak Siavashi
Assistant professor of orthopedic surgery
Tehran University of medical sciences
Sina Hospital, Imam Khomeini Street, Tehran, Iran
E-mail: [email protected]
Received Date: November 14, 2011; Accepted Date: December 13, 2011; Published Date: December 20, 2011
Citation: Siavashi B, Bahador R, Zehtab MJ (2012) Effectiveness of Celecoxib and Acetaminophen after Anterior Crutiate Ligament Reconstruction. Orthopedic Muscul Sys 1: 104. doi: 10.4172/2161-0533.1000104
Copyright: © 2012 Siavashi B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim: To evaluate the analgesic efficacy of administering Celecoxib as a component of multimodal analgesia for patients undergoing anterior cruciate ligament reconstruction surgery.
Methods: We conducted a randomized double blind placebo controlled clinical trial and included all 90 patients who were going to treated with ACL reconstruction in Sina Hospital during 2009-2010. After obtaining written informed consent, we administered Celecoxib 400 mg and Acetaminophen 750 mg 1-2 hours preoperatively to one group (43 patients) and placebo and the same dosage of acetaminophen to the second (47 patients). Postoperatively, all patients received Acetaminophen 750 mg every 6 hours in addition to Celecoxib 200 mg every 12 hours for case group or placebo for controls. This analgesic regimen continued for duration of 2 weeks in which all patients participated in a aggressive rapid rehabilitation program. The patients were evaluated at the end of 2nd week and 6th month. Data analysis performed using SPSS.
Results: Patients of two groups were similar with respect to probable confounder variables such as age, sex, weight, level of activity, side of operated knee and the duration of operation. Patellofemoral complications were observed in 13 and 39 patients of case and control group, respectively. The difference was statistically significant. However, the difference between the rate of observed regional pain syndrome among patients of two groups were not statistically significant.
Conclusion: It seems that using Celecoxib as a component of multimodal analgesia leads to increase patient cooperation in participation to rehabilitation program and finally improve the outcomes.