alexa Effectiveness of Time Domain and Spectral Domain Optica
ISSN: 2376-0389

Journal of Multiple Sclerosis
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Research Article

Effectiveness of Time Domain and Spectral Domain Optical Coherence Tomograph to Evaluate Eyes with And Without Optic Neuritis in Multiple Sclerosi Patients

Iester M*1, Cordano C1,2, Costa A1, D’Alessandro E1, Panizzi A1, Bisio F1, Masala A1, Landi L1, Traverso CE1, Ferreras A3, Mancardi GL2 and Uccelli A2

1Clinica Oculistica, DiNOGMI, University of Genoa, Italy

2Clinica Neurologica, DiNOGMI, University of Genoa, Italy

3University Eye Clinic of Zaragoza, Spain

*Corresponding Author:
Michele Iester
University Eye Clinic
Viale Benedetto XV, 5, 16132 Genoa, Italy
Tel: 00 39 010 353 7783
E-mail: [email protected]

Received March 01, 2016; Accepted May 11, 2016; Published May 17, 2016

Citation: Iester M, Cordano C, Costa A, D’Alessandro E, Panizzi A, et al. (2016) Effectiveness of Time Domain and Spectral Domain Optical Coherence Tomograph to Evaluate Eyes with And Without Optic Neuritis in Multiple Sclerosi Patients. J Mult Scler (Foster City) 3:173. doi:10.4172/2376-0389.1000173

Copyright: © 2016 Iester M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Purpose: To compare the macular assessment and retinal nerve fiber layer (RNFL) thickness by using two different optical coherence tomographies (OCTs): a time domain (TD) and a spectral domain (SD) OCT, in multiple sclerosis (MS) patients with and without unilateral optic neuritis (ON).

Methods: We enrolled 34 patients (13 males and 21 females): 18 without previous episodes of ON and16 with a previous monolateral episode of ON occurred at least 3 months prior to examination. Patients underwent ophthalmological examination, TD OCT and SD OCT scans. We compared the outcomes of eyes with and without ON by using Student’s t test.

Results: In the affected eye group a reduction of the average RNFL was found using TD OCT (reduction of 22.8%) with the difference between the two groups being statistically significant (p<0.05) in almost all the investigated retina areas. Similar results were found when eyes were analysed with SD OCT, also when the ganglion cell layer (GCC) was considered: a reduction of 18.1% of GCC average thickness was found. No significant difference was found when the outer retina was considered.

Conclusions: In MS patients both OCT systems were able to detect a difference between eyes with an outcome of optic neuritis and those without optic neuritis.


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