alexa Effectiveness of Topical Steroid Therapy for Prevention of Regorafenib associated Hand-foot Skin Reaction
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

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Research Article

Effectiveness of Topical Steroid Therapy for Prevention of Regorafenib associated Hand-foot Skin Reaction

Ishikawa H1*, Hamauchi S2, Tanaka R1, Shino M1 and Yamazaki K2

1Department of Pharmacy, Shizuoka Cancer Center, Japan

2Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Japan

*Corresponding Author:
Ishikawa H
Department of Pharmacy
Shizuoka Cancer Center, Japan
Tel: +81-55-989-5222
E-mail: [email protected]

Received date: July 13, 2017; Accepted date: July 17, 2017; Published date: July 24, 2017

Citation: Ishikawa H, Hamauchi S, Tanaka R, Shino M, Yamazaki K (2017) Effectiveness of Topical Steroid Therapy for Prevention of Regorafenib-associated Hand-foot Skin Reaction. J Appl Pharm 9:248. doi: 10.21065/1920-4159.1000248

Copyright: © 2017 Ishikawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Hand-foot Skin Reaction (HFSR) often hinders completion of Regorafenib therapy. No established prophylaxis exists against multikinase inhibitor-associated HFSR and further improvement of prophylaxis for HFSR is needed. Therefore, we offer multiagent therapy to prevent Regorafenib-associated HFSR comprising topical steroid (0.05% difluprednate) ointment and 20% urea-based cream.

Methods: Subjects were unresectable or recurrent colorectal cancer patients who started Regorafenib therapy between May 2013 and March 2014 at the Shizuoka Cancer Center. Electronic medical records were retrospectively examined for HFSR incidence, CTCAE v3.0 grade of severest HFSR, time of HFSR onset, rate of therapy termination, delay and dose reduction.

Results: Subjects were 55 patients and median treatment time 7.1 weeks. Overall and grade 3 HFSR incidence rate in this study (73 and 22%, respectively) was lower than in the CORRECT study Japanese subpopulation (80 and 28%, respectively). HFSR (grade ≥ 2) occurred in the first cycle or later in 42 and 11% of patients, respectively. HFSR accounted for 33 and 61% of first-cycle Regorafenib delay and dose reductions, respectively, and HFSR accounted for 40 and 53% in any cycle, respectively.

Conclusion: Effectiveness of prophylactic topical steroids against Regorafenib-associated HFSR was shown in this study. Therefore, this prophylaxis is applicable in clinical settings.

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