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ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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Research Article

Effects of an Acute Exercise on Endothelium Function in Athletics Young Subjects: A Case Control Study

Mohamed Sami Zguira1,2,3*, Ibtissem Khouaja1, Firas Zghal1, Hamdi Zguira1, Haythem Debbabi1, Bernard Saiag3 and Zouhair Tabka1

1Clinical Laboratory of Physiology, Medical School of Sousse, Sousse, Tunisia

2Research Unit: Secondary prevention after myocardial infarction, Faculty of Medicine of Sousse, Sousse, Tunisia

3Laboratory “Movement Sport and health Sciences”, ENS Cachan –antenne de Bretagne, Campus Ker Lann, Bruz, France

*Corresponding Author:
Mohamed Sami Zguira
Laboratory “Movement Sport and health Sciences”
ENS Cachan –antenne de Bretagne
Campus Ker Lann, Bruz, France
Tel: 216-73 222 600
Fax: 216-73 224 899
E-mail: [email protected]

Received date: October 26, 2015; Accepted date: November 10, 2015; Published date: November 15, 2015

Citation: Zguira MS, Khouaja I, Zghal F, Zguira H, Debbabi H, et al. (2015) Effects of an Acute Exercise on Endothelium Function in Athletics Young Subjects: A Case Control Study. Cardiovasc Pharm Open Access 4:163. doi:10.4172/2329-6607.1000163

Copyright: © 2015 Zguira MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: to investigate vascular reactivity on forearm skin blood flow (FSBF) in response to iontophoresis of acetylcholine (ACh) after an acute exercise.

Materials and method: 49 healthy male subjects 29 trained and 20 sedentary (recruited according to their oxygen consumption) participated in this case control study (mean age: 15 ± 1 year). Incremental exercise testing was performed by means of an individualized and personalized exercise test protocol. FSBF was measured before and after exercise using a laser Doppler flowmeter in response to local iontophoresis of a cumulative dose of ACh.

Results: Although groups were not different in age, height or body mass index, weight, resting heart rate, maximum oxygen consumption was significantly different (sedentary 40.05 ± 4.53 and trained 51.65 ± 5.76 ml.min-1. kg-1) (p<0.05; p<0.001; p<0.001, respectively). The mean response of FSBF to ACh was significantly increased after incremental exercise in the two groups (349%). Maximal FSBF response to ACh was significantly greater in trained (987% ± 78) than in sedentary (638% ± 42) (p=0.001) after a single acute exercise.

Conclusion: Response of FSBF to ACh-induced endothelium dependent relaxation was affected by the level of training whether before or after an acute exercise.


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