alexa Effects of Antioxidants on the Viability of the Human Neuroblastoma SH-SY5Y Cell Culture under the Conditions of Heavy-Metal Toxicity | OMICS International | Abstract
ISSN: 0974-8369

Biology and Medicine
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Research Article

Effects of Antioxidants on the Viability of the Human Neuroblastoma SH-SY5Y Cell Culture under the Conditions of Heavy-Metal Toxicity

Olga Igorevna Kulikova1,2*, Tatiana Nikolaevna Fedorova1, Alexander Vasilievich Lopachev1,3, Valentina Sergeevna Orlova2, Vladimir Alexandrovich Grachev2

1Research Center of Neurology, 80, Volokolamskoe Shosse, Moscow 125367, Russia

2Peoples’ Friendship University of Russia, 6, Miklukho-Maklaya Str., Moscow 117198, Russia

3A.N. Bach Institute of Biochemistry of the Russian Academy of Sciences, Leninsky Prospekt, 33, Build. 2, Moscow 119071, Russia

Corresponding Author:
Kulikova OI
Research Center of Neurology, 80
Volokolamskoe Shosse, Moscow 125367, Russia
E-mail: [email protected]

Received Date: April 27, 2016; Accepted Date: May 17, 2016; Published Date: May 25, 2016

Citation: Kulikova OI, Fedorova TN, Lopachev AV, Orlova VS, Grachev VA (2016) Effects of Antioxidants on the Viability of the Human Neuroblastoma SH-SY5Y Cell Culture under the Conditions of Heavy Metal Toxicity. Biol Med (Aligarh) 8:305. doi:10.4172/0974-8369.1000305

Copyright: © 2016 Kulikova et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Protective action of antioxidants (mexidol, carnosine, N-acetyl cysteine) and the metal chelator Ca, Na2-EDTA was studied in the culture of human neuroblastoma SH-SY5Y cells after the addition of salts of heavy metals—lead, cadmium, cobalt, and molybdenum—to the culture medium. Cells were incubated with heavy metals and protectors for 24 h, and cell viability and cell death were evaluated. All the metals lowered cell viability in a concentration-related manner. Different protective agents were studied based on this model. The most pronounced capability of increasing the cell viability in conditions of heavy-metal toxicity was demonstrated by N-acetyl cysteine (the protective effect was demonstrated at the concentrations 0.5-1.0 mM and higher). Protective potential of carnosine was somewhat lower and that of mexidol was minimal.

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