alexa Effects of Atorvastatin and Niacin, Alone and in Combination, On Lowering Serum LDL-Cholesterol and Lipoprotein (a) in Hyperlipidemia Patients
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Effects of Atorvastatin and Niacin, Alone and in Combination, On Lowering Serum LDL-Cholesterol and Lipoprotein (a) in Hyperlipidemia Patients

Jhuma KA1*, Giasuddin ASM2, Haq AMM3, Huque MM3 and Mahmood N4
1Department of Biochemistry, Medical College for Women & Hospital, Plot-4, Road-9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh
2Department of Medical Laboratory Science, State College of Health Sciences & Adjunct Professor, State University of Bangladesh, Dhanmondi, Dhaka-1209, Bangladesh
3Department of Medicine, Medical College for Women & Hospital, Plot-4, Road-9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh
4Department of Medicine, (Nephrology Unit), Medical College for Women & Hospital, Plot-4, Road-9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh
Corresponding Author : Khadija Akther Jhuma
Associate Professor of Biochemistry
Department of Biochemistry
Medical College for Women & Hospital
Plot-4, Road-9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh
Tel: 088-02-8913939
E-mail: [email protected]
Received February 17, 2014; Accepted March 11, 2014; Published March 20, 2014
Citation: Jhuma KA, Giasuddin ASM, Haq AMM, Huque MM, Mahmood N (2014) Effects of Atorvastatin and Niacin, Alone and in Combination, On Lowering Serum LDL-Cholesterol and Lipoprotein (a) in Hyperlipidemia Patients. J Metabolic Synd 3:136. doi:10.4172/2167-0943.1000136
Copyright: © 2014 Jhuma KA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background & objectives: Effects of statins on serum lipids in hyperlipidemia are not well defined. We compared the effects of atorvastatin and niacin, alone and combination, on lowering serum LDL-C and Lp (a) and increasing HDL-C in hyperlipidemia patients.

Patients and methods: A total of 150 adult patients (Group-A) with hyperlipidemia and 100 normal adults controls (Group-B) were included in the study. The fasting blood samples were taken and serum (I°) were stored frozen until analysed for TG, TC, LDL-C, HDL-C, and Lp (a). The 50 patients (Group A1) were prescribed Atorvastatin (10 mg once daily for 3 months), 50 patients (Group A2) were prescribed Niacin (50 mg twice daily for 3 months) and 50 patients (Group A3) were prescribed combination of the two drugs with same doses for 3 months. Blood samples were taken again at follow up and serum (II°) was stored frozen until analysed for lipids by biochemical methods.

Results: Lipid parameters (mg/dl), i.e. TG, TC, LDL-C, & Lp(a), were raised and HDL-C was reduced in patients (Group-A) compared to controls (Group-B); Atovastatin (10 mg/ day) and Niacin (50 mg/2day) significantly lowered TG,TC, LDL-C & Lp(a) and raised HDL-C in Group A1 and Group A2 respectively; Combination therapy (atorvastatin: 10 mg/day + Niacin : 50 mg*2/day) was much more effective in lowering TG, TC, LDL-C & LP(a) and raising HDL-C in Group A3.

Conclusions: The effects of combination therapy of the two drugs were much higher than their effects alone and therefore, can be adopted in hyperlipidemia patients.

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