alexa Effects of Caffeine on Salivation
ISSN: 2471-8726

Oral Health Case Reports
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Case Report

Effects of Caffeine on Salivation

Andrei Barasch1* and Sara C Gordon2

1Department of Medicine, Weill Cornell Medical College, New York, USA

2Depatment of Oral Pathology and Medicine, University of Washington at Seattle School of Dentistry, Seattle, WA, USA

*Corresponding Author:
Andrei Barasch
DMD, MDSc, Department of Medicine
Division of Oncology, Weill Cornell Medical Center
525 East 68th Street, New York, NY 10065, USA
E-mail: [email protected]

Received date: February 05, 2016; Accepted date: February 19, 2016; Published date: February 24, 2016

Citation: Barasch A, Gordon SC (2016) Effects of Caffeine on Salivation. Oral health case Rep 1:107. doi:10.4172/2471-8726.1000107

Copyright: © 2016 Barasch A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Caffeine is a methylxanthine which may decrease salivation through adrenergic mechanisms. Few studies have formally tested whether caffeine actually decreases saliva production. Methods: Eleven volunteers collected unstimulated 1-minute saliva production (1-MSP) after an overnight fast, followed shortly by a stimulated 1-MSP while chewing a stick of chewing gum. We then asked them to drink a beverage randomly selected to contain either regular or decaffeinated instant coffee. Caffeine content was doubleblinded. 1-MSP, both unstimulated and stimulated were then collected 30, 60, 90, and 120 minutes later. The following morning the subject followed the same protocol but drank the other kind of beverage. We used a mixedeffects linear model to analyze our data. Results: The adjusted mean difference between decaffeinated and caffeinated 1-MSP was -0.14 ml (p<0.05). Stimulation with chewing gum caused an unadjusted increase of 2.02 ml (p<0.001) and an adjusted increase of 2.01 ml (p<0.05). Variation for the unstimulated 1-MSP was much lower (SD 0.4 ml) than the stimulated 1-MSP (SD 1.01 ml), whereas variation for caffeinated 1-MSP (SD 1.29 ml) was similar to decaffeinated 1-MSP (SD 1.25 ml). Conclusion: Caffeine modestly but significantly decreased both Unstimulated and stimulated saliva production. The effect of caffeine was approximately 6.5% that of stimulation. The effect from caffeine was consistent across both stimulated and unstimulated samples. Additionally, caffeine did not increase the variability of saliva production either within or between individuals, in contrast to the effect from stimulation


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