Effects of Celecoxib or Omega-3 Fatty Acids Alone and in Combination with Risperidone on the Behavior and Brain Biochemistry Using Amphetamine-Induced Model of Schizophrenia in Rats
Enass Yossef Osman*
Department of Pharmacology and Toxicology, College of Pharmacy, Tanta University, Egypt
- *Corresponding Author:
- Enass Yossef Osman
Department of Pharmacology and Toxicology
College of Pharmacy, Tanta University
38 EL-Gish street, Tanta, Egypt, Postal code 31511
Tel: +20 40 3452372
E-mail: [email protected]
Received date: April 13, 2016; Accepted date: April 28, 2016; Published date: April 30, 2016
Citation: Osman EY (2016) Effects of Celecoxib or Omega-3 Fatty Acids Alone and in Combination with Risperidone on the Behavior and Brain Biochemistry Using Amphetamine-Induced Model of Schizophrenia in Rats. J Pharma Reports 1:116. doi:10.4172/jpr.1000116
Copyright: © 2016 Osman EY. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Study background: The implication of oxidative stress and neuro-inflammation in the pathogenesis of schizophrenia has been elucidated. Antipsychotics have limited effectiveness against negative symptoms of schizophrenia and are associated with adverse effects. The use of celecoxib or omega-3 in schizophrenia may have beneficial effects. This study was to evaluate the possible efficacies of celecoxib, omega-3 or the combination of celecoxib+risperidone and omeg-3+risperidone compared to risperidone on behavior and brain biochemistry in rats. Method: An amphetamine-induced model of schizophrenia in adult male rats was used to evaluate the effects of celecoxib, omega-3, celecoxib+risperidone and omega-3+risperidone on the behavior of animals and on brain lipid peroxidation or tumor necrosis factor-alpha. Results In the water maze task, celecoxib, omega-3, celecoxib+risperidone, omega-3+risperidone significantly decreased the latency time and increased the swimming speeds compared to amphetamine-treated group. celecoxib, omega-3, celecoxib+risperidone, omega-3+risperidone also significantly reversed the decreased spontaneous alternation induced by amphetamine in the Y-maze task. In the social interaction task, groups treated with celecoxib, omega-3, celecoxib+risperidone, omega-3+risperidone spent less time to recognize foreign animals than animals in the amphetamine-treated group. Increased brain MDA and TNF-α level due to amphetamine were significantly reduced in groups treated with celecoxib+risperidone or omega-3+risperidone. Conclusion: Celecoxib or omega-3 can attenuate amphetamine- induced behavioral impairment. These effects may be associated with their ability to decrease lipid peroxidation and cytokine release. Celecoxib or omega-3 may be promising candidates for treating such disease.