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ISSN: 2155-9600

Journal of Nutrition & Food Sciences
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Research Article

Effects of Chow and Liquid Diet on Liver Integrity and Antioxidant Defense in Sleep-Deprived Male Rats

Paulo JF Martins1, Ligia A Azzalis2, Allan C de Oliveira1, Leandro Fernandes1, Sergio Tufik1 and Vânia D’Almeida1*

1Department of Psychobiology, Federal University of Sao Paulo - UNIFESP/ São Paulo, Brazil

2Department of Exact and Earth Sciences, Federal University of São Paulo - UNIFESP / Diadema, Brazil

*Corresponding Author:
Vânia D’Almeida
Department of Psychobiology, Federal University of Sao Paulo
Rua Napoleon de Barros, 925, 3rd floor
Sao Paulo, SP 04024-002, Brazil
Tel: +55 11 2149 0155x283
Fax: +55 11 5572 5092
E-mail: [email protected]

Received date: August 19, 2013; Accepted date: September 14, 2013; Published date: September 17, 2013

Citation: Martins PJF, Azzalis LA, de Oliveira AC, Fernandes L, Tufik S, et al. (2013) Effects of Chow and Liquid Diet on Liver Integrity and Antioxidant Defense in Sleep-Deprived Male Rats. J Nutr Food Sci 3:228. doi:10.4172/2155-9600.1000228

Copyright: © 2013 Martins PJF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The influence of diet composition and availability on liver and antioxidant system function under sleep deprivation (SD) in rats is not completely known. We have previously demonstrated that chow-fed sleep-deprived rats lose weight and present a starvation-like metabolic and hormonal profile, accompanied by hyperphagia. On the other hand, liquid diet attenuates weight loss and the endocrine-metabolic effects associated to SD. It is widely known that energy metabolism is strongly correlated with the production of free radicals and that oxidative cell damage may occur. Our objective was to verify whether the two different diets offered during SD would also affect antioxidant defense system and liver integrity. Male rats were distributed into the following groups: control, sleep-deprived for 96 h by the platform technique (SD-96h) or SD-96h recovered for 24 h (Rebound). Rats were fed with chow pellets (CP) or a liquid diet (LD). Our results show that the CP rats showed changes in antioxidant defense parameters and liver damage markers after SD. However, such changes were attenuated in rats fed the liquid diet. We conclude that the attenuated effect of LD on some studied liver damage and antioxidant defense markers lead us to suggest that these changes are at least partially linked to energy deficits induced by SD.

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