alexa Effects of Delayed Release Microsphere of Exenatide on Peri-Implant Bone Response of Diabetic Rats
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Short Communication

Effects of Delayed Release Microsphere of Exenatide on Peri-Implant Bone Response of Diabetic Rats

Wenjuan Zhou1,2, Stefan Tangl4,5, Fei Chi2, Xilong Yue2, Shutai Liu2, Zhonghao Liu2 and Xiaohui Rausch-Fan1,3*

1Competent Center of Periodontal Research, Dental School of Medical University, Vienna, Austria

2Department of Dental Implantology, Affiliated Hospital of Stomatology of Yantai, Binzhou Medical University, Yantai, China

3Division of Conservative Dentistry and Periodontology, Dental School of Medical University, Vienna, Austria

4Division of Oral Surgery, Dental School of Medical University, Vienna, Austria

5Cluster for Tissue Regeneration, Vienna, Austria

*Corresponding Author:
Xiaohui Rausch-Fan
Professor, Competent Center of Periodontal Research
Division of Conservative Dentistry and Periodontology
Dental School of Medical University, Sensengasse 2a, 1090, Vienna, Austria
Tel: +43 / 1 / 40070-4748
Fax: +43 / 1 / 40070-4709
E-mail: [email protected]

Received date : August 23, 2015; Accepted date : September 03, 2015; Published date : September 14, 2015

Citation: Zhou W, Tangl S, Chi F, Yue X, Liu S, et al. (2015) Effects of Delayed Release Microsphere of Exenatide on Peri-Implant Bone Response of Diabetic Rats. Dentistry 5:335. doi:10.4172/2161-1122.1000335

Copyright: © 2015 Zhou W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: The aim of this study is to evaluate and compare the impact of delayed release microsphere of exenatide on dental implants treatment of diabetic rats.

Materials and methods: 6 male Zucker Diabetic Fatty (ZDF) rats were divided into three groups: GroupA, diabetic rats with dental implants (controls). Group B, diabetic rats treated with exenatide and implants placed simultaneously. Group C, diabetic rats treated with exenatide until serum glucose at a constant level and then implants were placed. Implants with surrounding bone tissues were harvested and bone responses were assessed by histomorphometric analysis.

Results: Osseointegration of all implants had proceeded, bone response to implant surface of one implant in group A was similar to that in group B and C, and implants were surrounded by dense, very compact bone, osteocytes were deposited in lamellar bone in group C.

Conclusion: The present study of dental implants with Diabetes mellitus suggested that the process of osseointegration is affected by diabetes, early osseointegration can be enhanced in individuals with well-controlled diabetes, but the included samples were too small to get a statistical conclusion, further well designed comparative studies are needed to explore the exact effect of diabetes and metabolic control on bone response to dental implants.


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