alexa Effects of IgM Anti-Galnac-GD1a Monoclonal Antibody on Neuromuscular Transmission and Calcium Channel Binding in the Rat Neuromuscular Junction
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Effects of IgM Anti-Galnac-GD1a Monoclonal Antibody on Neuromuscular Transmission and Calcium Channel Binding in the Rat Neuromuscular Junction

Sayako Hotta1, Takumi Nagaoka1, Yoshihiko Nakatani1, Toshie Kambe2, Kenji Abe3, Yutaka Masuda4, Iku Utsunomiya5 and Kyoji Taguchi1*

1Department of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan

2Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan

3Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan

4Laboratory of Clinical Pharmacy, Machida, Tokyo, Japan

5Developmental Education, Showa Pharmaceutical University, Machida, Tokyo, Japan

Corresponding Author:
Kyoji Taguchi
Department of Medicinal Pharmacology
Showa Pharmaceutical University
3-3165 Higashitamagawagakuen
Machida, Tokyo 194-8543, Japan
Tel: +81-42-721-1594
Fax: +81-42-721-1588
E-mail: [email protected]

Received date: January 05, 2015; Accepted date: March 16, 2015; Published date: March 23, 2015

Citation: Hotta S, Nagaoka T, Nakatani Y, Kambe T, Abe K, et al. (2015) Effects of IgM Anti-Galnac-GD1a Monoclonal Antibody on Neuromuscular Transmission and Calcium Channel Binding in the Rat Neuromuscular Junction. J Neurol Neurophysiol 6:275. doi:10.4172/2155-9562.1000275

Copyright: © 2015 Hotta S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Guillain-Barré syndrome with antibodies against ganglioside N-acetylgalactosaminyl GD1a (GalNAc-GD1a) is
characterized by a rapid onset of predominantly distal pure motor neuropathy. However, the pathogenic role of anti-
GalNAc-GD1a antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. We investigated
the effects of IgM anti-GalNAc-GD1a monoclonal antibody (IgM anti-GalNAc-GD1a mAb) on spontaneous muscle
action potentials (SMAP) in a rat spinal cord–muscle co-culture system and the localization of IgM anti-GalNAc-
GD1a mAb and calcium channel binding in the rat hemi-diaphragm. Immunohistochemistry of the rat hemidiaphragm
showed that IgM anti-GalNAc-GD1a mAb binding overlapped with anti-neurofilament 200 antibody and α-
bungarotoxin staining, demonstrating that IgM anti-GalNAc-GD1a mAb was localized at the motor nerve terminal.
Moreover, IgM anti-GalNAc-GD1a mAb binding overlapped with anti-Cav2.1 antibody in the nerve terminal. We
suggest that the inhibitory effect of IgM anti-GalNAc-GD1a mAb on SMAP is related to the GalNAc-GD1a epitope on
P/Q-type calcium channels in motor nerve terminals at NMJs.

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