alexa Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism | OMICS International | Abstract
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
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Research Article

Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism

Mancini A1*, Raimondo S1, Di Segni C1, Persano M1, Cammarano M1, Pontecorvi A1, Festa R2, Tiano L3, Silvestrini A4 and Meucci E4

1Department of Medical Sciences, Division of Endocrinology, The Catholic University School of Medicine, Rome, Italy

2Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy

3Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy

4Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy

*Corresponding Author:
Mancini A
Department of Medical Sciences
Division of Endocrinology
The Catholic University School of Medicine
Rome, Italy
Tel: +39-30154440
Fax: +39-0630157232
E-mail: [email protected]

Received date: June 03, 2013; Accepted date: July 22, 2013; Published date: July 30, 2013

Citation: Mancini A, Raimondo S, Di Segni C, Persano M, Cammarano M, et al. (2013) Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism. J Steroids Horm Sci 4:117. doi:10.4172/2157-7536.1000117

Copyright: © 2013 Mancini A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


From cross-sectional studies in healthy men, lower plasma total testosterone levels seem to be associated with hyperinsulinemia, decreased glucose tolerance, and a higher level of cardiovascular risk factors. Despite in vitro and in vivo experiments suggest a key role of testosterone in modulating antioxidant systems in different tissues, few data are reported in humans. Extending our previous results, we show that treatment with testosterone, both in intramuscular or bioadhesive buccal formulations, increase plasma levels of Coenzyme Q10, lipophilic antioxidant, and total antioxidant capacity, measured with colorimetric method, in patients with secondary hypogonadism. Hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk in such patients.


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