alexa Effects of Mangosteen Pericarp Extracts Against Mammary Cancer | OMICS International | Abstract
ISSN: 2327-5162

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Effects of Mangosteen Pericarp Extracts Against Mammary Cancer

Masa-Aki Shibata1*, Yoshinobu Matoba2, Hideki Tosa3 and Munekazu Iinuma4

1Laboratory of Anatomy and Histopathology, Graduate School of Health Sciences, Osaka Health Science University, Japan

2Komeda Pharmaceutical Co., Ltd., Japan

3Field & Device Co., Japan

4Laboratory of Pharmacognosy, Gifu Pharmaceutical University, Japan

*Corresponding Author:
Masa-Aki Shibata
Laboratory of Anatomy and Histopathology
Graduate School of Health Sciences, Osaka Health Science University
1-9-27 Temma, Kita-ku, Osaka, 530-0043, Japan
Tel: +81-6-7506-9046
Fax: +81-6-6352-5995
E-mail: [email protected]

Received date August 20, 2013; Accepted date September 20, 2013; Published date September 23, 2013

Citation: Shibata MA, Matoba Y, Tosa H, Iinuma M (2013) Effects of Mangosteen Pericarp Extracts Against Mammary Cancer. Altern Integr Med 2:139. doi:10.4172/2327-5162.1000139

Copyright: © 2013 Shibata MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The pericarp of the mangosteen fruit, Garcinia mangostana Linn, has a long history of use as a medicinal plant in Southeast Asia. The actions of mangosteen extracts have been scientifically supported and it has become a popular natural health-promoting dietary supplement. Mangosteen extracts, particularly α-mangostin, induced apoptosis via the mitochondrial pathway, cell cycle arrest by p21cip1 induction and Akt dephsophorylation in mammary cancer cells; these anti-proliferative effects are associated in vivo with suppression of tumor growth and metastasis in mouse mammary cancer models. Such preclinical evidence suggests that mangosteen extracts have potential chemotherapeutic and/or chemopreventive uses


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