alexa Effects of Melatonin upon Vascularity of Cartilage End Plate of Intervertebral Disc | OMICS International
ISSN: 2165-7939

Journal of Spine
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Editorial

Effects of Melatonin upon Vascularity of Cartilage End Plate of Intervertebral Disc

Yigit Uyanikgil1,2, Emel Oykü Cetin3 and Mehmet Turgut4*
1Department of Histology and Embryology, Ege University, School of Medicine, Izmir, Turkey
2Cord Blood, Cell-Tissue Research and Application Center, Ege University, Izmir, Turkey
3Department of Pharmaceutical Technology, Biopharmaceutics and Pharmacokinetics, Ege University, Faculty of Pharmacy, Izmir, Turkey
4Department of Neurosurgery, Adnan Menderes University, School of Medicine, Aydin, Turkey
*Corresponding Author : Mehmet Turgut, M.D., PhD
Cumhuriyet Mahallesi
Adnan Menderes Bulvarı
Haltur Apartmanı No: 6/7
09020 Aydın, Turkey
Tel: +90 256 2134874
Fax: +90. 256.2120146
E-mail: [email protected]
Received: April 03, 2016; Accepted: April 05, 2016; Published: April 07, 2016
Citation: Uyanikgil Y, Cetin EO, Turgut M (2016) Effects of Melatonin upon Vascularity of Cartilage End Plate of Intervertebral Disc. J Spine 5:e123. doi:10.4172/2165-7939.1000e123
Copyright: © 2016 Uyanikgil Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Anatomically, intervertebral disc (IVD) consists of three part; nucleus pulposus, annulus fibrosus and cartilage end plate (CEP) at the cranial and caudal vertebral interface of the disc. In both animals and humans, the IVD consists largely of extracellular matrix with a low cell density. In many respects, that degeneration and age- related changes are characterised by biochemical and structural changes components of the IVD.

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