Effects of Mercury Chloride on Oxidative Stress Biomarkers of Some Tissues of the African Catfish Clarias gariepinus (Burchell, 1822)Ahmed Th A Ibrahim*
Zoology Department, Faculty of Science (New Valley Branch), Assiut University, Egypt
- *Corresponding Author:
- Ahmed Th A Ibrahim
Zoology Department Faculty of Science
(New Valley Branch) Assiut University Egypt
Tel: +20 88 2423333
E-mail: [email protected]
Received date: May 25, 2015 Accepted date: July 22, 2015 Published date: July 24, 2015
Citation:Ibrahim ATA (2015) Effects of Mercury Chloride on Oxidative Stress Biomarkers of Some Tissues of the African Catfish Clarias gariepinus (Burchell, 1822). J Veterinar Sci Technol 6: 242. doi:10.4172/2157-7579.1000242
Copyright: ©2015 Ibrahim ATA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study evaluates in Clarias gariepinus the oxidative damage associated with two sub-chronic exposures to mercury chloride. The destructive effects of mercury chloride on the African Catfish, Clarias gariepinus was revealed in terms of protein carbonyl (PC), lipid peroxidation (LPO), DNA damage and nitric oxide (NO) as oxidative stress biomarkers. Super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), glutathione reductase (GR), glutathione-s-Transferase (GST), glutathione (GSH) and total antioxidant (TAO) in the gills, kidney and liver can be used as biomarkers to identify possible environmental contamination in fish. This study aimed to investigate the impact of HgCl2 (0.04 and 0.12 ppm) for 14 and 28 days of the activity of the selected parameters in different tissues of Clarias gariepinus. The activity of SOD, CAT, Gpx and TAO dropped when compared to the control groups without mercury chloride exposure in all tissues under investigation. The pattern of variations in GST, GR and GSH activity in mercuryinduced groups were significantly increased than that of the control group. Also, NO, CP, LPO and DNA damage, were recorded with a pattern of a significant increase toward exposure period in all tissues under investigation.