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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Effects of Moderate Intensity Physical Training in Neonatal Alloxan- Administered Rats

Carla Ribeiro*, Clécia Soares de Alencar Mota, Fabrício Azevedo Voltarelli, Michel Barbosa de Araújo, José Diego Botezelli, Camila Aparecida Machado de Oliveira and Maria Alice Rostom de Mello

Department of Physical Education, São Paulo State University (UNESP), Rio Claro-SP, Brazil.

*Corresponding Author:
Carla Ribeiro
Avenue. 24 A, 1515, Bela Vista – Rio Claro–SP, CEP 13506-900
Institute of Biosciences, Department of Physical Education
São Paulo State University (UNESP), Rio Claro-SP, Brazil
Tel: +55 19 35264308
E-mail: [email protected]

Received date: October 27, 2010; Accepted date: October 30, 2010; Published date: November 02, 2010

Citation: Ribeiro C, de Alencar Mota CS, Voltarelli FA, de Araújo MB, Botezelli JD, et al. (2010) Effects of Moderate Intensity Physical Training in Neonatal Alloxan- Administered Rats. J Diabetes Metab 1:107. doi: 10.4172/2155-6156.1000107

Copyright: © 2010 Ribeiro C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Newborn rats (6 days old) received alloxan intraperitoneally (A= 250 mg/kg b.w). Rats injected with vehicle (citrate buffer) were used as controls (C). After weaning, half of the animals were submitted to 1 hour/day, 5 days/week swimming and with supporting overload of 5% b.w. At 28 days, no signi fi cant differences were found among the groups in fasting glycemia and insulinemia. At 60 days, the fasting glycemia (30 min after oral glucose administration) was higher in alloxan than in controls groups and lower in the alloxan group submitted to training than in the correspondent sedentary group. The glucose tolerance of the alloxan rats was reduced in comparison to controls, both at 28 and 60 days, since the area under the blood glucose curve during the OGTT was higher in the alloxan than in the control. No difference was found among the groups both at 28 and 60 days in the HOMA index. However, a slight reduction was observed in the values of the trained groups suggesting slightly increased insulin sensitivity in the animals. These results suggest that this diabetes mellitus animal model presents interesting characteristics for the study of the role of the physical exercise in diabetes outcome.

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