Effects of Monacolin K of Red Rice and Glucomannan, Combined with a Low Calorie Diet, in Treatment of Dyslipidemia and HypertensionTeresa Esposito, Salvatore Allocca, Laura Adelfi, Giovanni Messina, Marcellino Monda* and Bruno Varriale
Department of Experimental Medicine, Second University of Naples, Naples, Italy
- Corresponding Author:
- Marcellino Monda, Professor
Department of Experimental Medicine
Section of Human Physiology, and
Clinical Dietetic Service, Second University of Naples
Via Costantinopoli 16, 80138 Naples, Italy
Tel: +39 +81 566 5804
Fax: +39 +81 5665841
E-mail: m[email protected]
Received date: July 27, 2015; Accepted date: September 05, 2015; Published date: September 12, 2015
Citation: Esposito T, Allocca S, Adelfi L, Messina G, Monda M, et al. (2015) Effects of Monacolin K of Red Rice and Glucomannan, Combined with a Low Calorie Diet, in Treatment of Dyslipidemia and Hypertension. Biol Med (Aligarh) 7:250. doi: 10.4172/0974-8369.1000250
Copyright: © 2015 Esposito T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Alarming increase in incidence of cardiovascular disease is result of a nutrition pattern characterized by an increase in consumption of fats, cholesterol, sugar and other refined carbohydrates, concomitant with low consumption of polyunsaturated fatty acids and fibers. The purpose of this study was to evaluate the efficacy of the monacolin K of red rice and glucomannan, associated with low-calorie diet, on improvement of lipid profile and hypertension, symptoms of metabolic syndrome. In 180 Neapolitan patients with metabolic syndrome, we evaluated effects of monacolin K of red rice and glucomannan, associated with a low-calorie diet, on total cholesterol (CT), LDL cholesterol (LDL), HDL cholesterol (HDL), triglycerides (TG) and blood pressure (BP). The results showed a significant decrease in average value of CT (-20%), LDL (-25%), TG (-20%), with an increase in HDL (+15%) and a decrease in BP (-20%). These findings corroborate evidences showing a therapeutic effects of these nutraceuticals in the treatment of dyslipidemia and hypertension, when a low-calorie diet alone is ineffective.