alexa Effects of Onabotulinum Toxin A Intradetrusor Injection
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Effects of Onabotulinum Toxin A Intradetrusor Injections on Urinary Symptoms and Sexual Life in Women Affected by Multiple Sclerosis: A Prospective Controlled Study

Antonella Giannantoni1*, Marilena Gubbiotti1, Jacopo Adolfo Rossi de Vermandois1, Eleonora Salvini1, Silvia Proietti2, Savino M Di Stasi1 and Ettore Mearini1

1Department of Surgical and Biomedical Sciences, Uro-Oncology Section, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, 06100, Italy

2Department of Urology, Urological Research Institute, IRCCS San Raffaele Hospital, Milan, Italy

Corresponding Author:
Antonella Giannantoni
Department of Surgical and Biomedical Sciences
Urology and Andrology Section
University of Perugia
Ospedale S. Maria della Misericordia
Perugia, 06100, Italy
Tel: +39 075 5783898
Fax: +39 075 5784416
E-mail: [email protected]

Received date: February 27, 2017; Accepted date: May 31, 2017; Published date: June 07, 2017

Citation: Giannantoni A, Gubbiotti M, de Vermandois JAR, Salvini E, Proietti S, et al. (2017) Effects of Onabotulinum Toxin A Intradetrusor Injections on Urinary Symptoms and Sexual Life in Women Affected by Multiple Sclerosis: A Prospective Controlled Study. J Neurol Neurophysiol 8:427. doi:10.4172/2155-9562.1000427

Copyright: © 2017 Giannantoni A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Voiding and sexual dysfunction in Multiple Sclerosis represent the most devastating dimensions of the disease. Pharmacological treatment of voiding dysfunction could improve sexual life in patients affected by the disease. We investigated the effects of Onabotulinum toxin A intradetrusor injections on urinary symptoms and sexual dysfunction, and on the psychological status of women affected by Multiple Sclerosis with refractory overactive bladder. Methods: 41 patients underwent neurologic and urologic clinical evaluations and were administered the Female Sexual Function Index, the Incontinence-Quality of Life questionnaire, the Hamilton Anxiety Rating Scale and the Hamilton Depression Rating Scale, before and six months after Onabotulinum toxin A intradetrusor injection; 21 continent females affected by the disease acted as controls. Results: At baseline, all patients were incontinent and 35/41 was sexually active, with low Female Sexual Function Index scores. Mild depression and anxiety were detected in all cases with a reduced quality of life. Six months after treatment, overactive bladder symptoms improved significantly in all patients. Arousal, lubrication, orgasm-related problems and desire alterations markedly improved, together with an improvement in anxiety, depression and quality of life. Scores of Female Sexual Function Index, Incontinence-Quality of Life questionnaire, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale remained unchanged in controls. Conclusion: Onabotulinum toxin A intradetrusor injections not only control overactive bladder symptoms in women affected by multiple sclerosis, but also significantly improve sexual life.


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