alexa Effects of Oral Rinse using Lemon-Flavored Water with or without Rebamipide on Fluoropyrimidine-Induced Stomatitis | OMICS International | Abstract
ISSN: 2329-6771

Journal of Integrative Oncology
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Research Article

Effects of Oral Rinse using Lemon-Flavored Water with or without Rebamipide on Fluoropyrimidine-Induced Stomatitis

Megumi Kabeya1*, Kenji Ina2*, Shu Yuasa1, Fumi Kikuchi1, Chiharu Tajiri1, Tae Kato1, Satoshi Hibi1, Yoko Minagawa1, Ryuichi Furuta2, Takaki Kikuchi3, Takashi Kanamori3, Satoshi Kayukawa3, and Takae Kataoka3

1Department of Hospital Pharmacy, Nagoya Memorial Hospital, Nagoya, Japan

2Department of Medical Oncology, Nagoya Memorial Hospital, Nagoya, Japan

3Department of Clinical Oncology, Nagoya Memorial Hospital, Nagoya, Japan

*Corresponding Author:
Kenji Ina
Department of Medical Oncology
Nagoya Memorial Hospital
4-305 Hirabari, Tenpaku-ku
Nagoya 468-8520, Japan
Tel: +81-52-804-1111
Fax: +81-52-803-8830
E-mail: [email protected]

Received date August 06, 2013; Accepted date September 07, 2013; Published date September 17, 2013

Citation: Kabeya M, Ina K, Yuasa S, Kikuchi F, Tajiri C, et al. (2013) Effects of Oral Rinse using Lemon-Flavored Water with or without Rebamipide on Fluoropyrimidine-Induced Stomatitis. J Integr Oncol 2:107. doi:10.4172/2329-6771.1000107

Copyright: © 2013 Kabeya M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: To examine the efficacy of oral rinsing against chemotherapy-induced stomatitis.

Methods: Consecutive fluoropyrimidine-treated patients with stomach and colorectal cancer were enrolled from April 2009 to March 2011 (n=43; Group 1) and from January 2012 to December 2012 (n=45; Group 2). The incidence and severity of stomatitis were compared between Group 1 patients, who were instructed to gargle with lemonflavored water 6 times daily, and Group 2 patients, who did not receive any specific guidance. Among patients in the gargle group, we determined the rate of gargling compliance as well as quality of life (QOL) scores, and evaluated the impact of rebamipide use on patient outcomes.

Results: The incidence of stomatitis was significantly reduced in Group 1 (14.0%) compared to that in Group 2 (33.3%) and its severity in the former group was milder. Among patients using lemon-flavored water, concomitant rebamipide use had no statistically significant impact on stomatitis incidence (with versus without rebamipide, 19.0% versus 9.0%), the rate of gargling compliance (96.4% versus 94.2%), or QOL scores.

Conclusions: Oral rinse with lemon-flavored water is useful for the symptomatic control of fluoropyrimidineinduced stomatitis, regardless of the presence or absence of rebamipide.


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