alexa Effects of Orexin A on Thermal Behaviour: Substantial Evidences for Thermoregulatory Role of Orexin A
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effects of Orexin A on Thermal Behaviour: Substantial Evidences for Thermoregulatory Role of Orexin A

Emanuela Viggiano1, Giovanni Messina1, Andrea Viggiano2, Alessandro Viggiano1, Vincenzo De Luca3, Antonietta Messina1 and Marcellino Monda1*

1Department of Experimental Medicine-Section of Human Physiology, Second University of Naples, Naples, Italy

2Department of Medicine and Surgery, University of Salerno, Salerno, Italy

3Department of Psychiatry, University of Toronto, Toronto, Canada

*Corresponding Author:
Marcellino Monda
Department of Experimental Medicine
Section of Human Physiology
Second University of Naples
via S.M. di Costantinopoli
16, 80138 Naples, Italy
Tel: +390815665804
E-mail: [email protected]

Received Date: August 13, 2014; Accepted Date: October 28, 2014; Published Date: November 03, 2014

Citation: Viggiano E, Messina G, Viggiano A, Viggiano A, Luca VD, et al. (2014) Effects of Orexin A on Thermal Behaviour: Substantial Evidences for Thermoregulatory Role of Orexin A. J Bioanal Biomed 06:040-044. doi: 10.4172/1948-593X.1000108

Copyright: © 2014 Viggiano E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Orexin A is a hypothalamic neuropeptide produced in the dorsal and lateral hypothalamus, and orexin-producing cell have widespread anatomical projections within the central nervous system. Orexin A is involved in multiple physiological functions, including eating behavior, thermoregulation, and sleep-regulation. The aim of this work was to study the thermal preference induced by orexin A. A thermal preference task with floor thermal gradient from 16°C to 25°C, divided into 10 equal segments, was designed to evaluate the thermal preferences in rats. Male rats (n=10, divided into two groups of five animals) received an intracerebroventricular injection of 1.5 nmol of orexin A or vehicle and were subsequently tested for thermal preference for 4 h. The results showed that the rats injected with orexin A had increased motor activity compared to the control group, particularly after the second hour of the test. Moreover the group treated with orexin A preferred hotter temperatures ranging from 24 to 25°C compared to the control group that preferred temperature of 22°C, which is near room temperature for rat housing (22 ± 1°C). No significant correlation was seen between thermal preference and time (hours). Since orexin A induces thermal preference, this study indicates that this neuropeptide plays a key role in the thermoregulation.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version