alexa Effects of Perinatal 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Exposure on Development of Taste Preference in Rat Offspring
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effects of Perinatal 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Exposure on Development of Taste Preference in Rat Offspring

Nishijo M1*, Tran NN1, Nakagawa H1, Hori E2, Torii K3, Takashi K3 and Nishijo H2

1Department of Public Health, Kanazawa Medical University, Uchinada, 920-0293, Japan

2System Emotional Science, Graduate School of Medicine, University of Toyama, Toyama, 930-0194, Japan

3Frontier Research Laboratories, Institute for innovation, Ajinomoto Co., Inc., Kawasaki, 210-8681, Japan

*Corresponding Author:
Nishijo M
Department of Public Health, Kanazawa Medical University
1-1, Daigaku, Uchinada, Ishikawa 920-0293, Japan
Tel: +81-76-286-2211
Fax: +81-76-286-3728
E-mail: [email protected]

Received date: December 30, 2013; Accepted date: February 07, 2014; Published date: February 14, 2014

Citation: Nishijo M, Tran NN, Nakagawa H, Hori E, Torii K, et al. (2014) Effects of Perinatal 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Exposure on Development of Taste Preference in Rat Offspring. J Addict Res Ther 5:173. doi:10.4172/2155-6105.1000173

Copyright: © 2014 Nishijo M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Perinatal 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) exposure affects various motivated behaviors controlled by limbic system of the brain in offspring. In this study, effects of perinatal TCDD exposure on taste preference were investigated in the rat offspring whose dams were orally exposed to TCDD on the 15 gestational days. After weaning, offspring were given free access to six amino acid solutions with different tastes (sweet, umami, or bitter), saline (salty taste), and distilled water in a choice paradigm. In the TCDD exposed males, daily food intake was significantly decreased on Postnatal Day (P.D.) 33, whereas no differences of total fluid and any kind of solution intake were found between TCDD exposure and control groups in males. In the exposed females, daily intake of MSG was significantly lower on P.D. 32-34 respectively. Moreover, mean MSG intake rates during P.D. 29-35 was significantly decreased in TCDD exposure females. These results suggest that the TCDD-exposed females need less protein than the control females because of poorer growth than the control females, because MSG has “umami” taste, which reflects preference protein intake. In contrast, daily histidine intake on P.D. 34 was significantly increased in TCDD exposed females, and mean lysine intake rate during PND 29-35 was significantly higher than that of control group. These results suggest that rats preferred bitter taste of histidine and lysine solutions under the chemical stress of TCDD exposure. In conclusion, perinatal TCDD exposure affected development of taste preference of offspring female rats, and more study to clarify neural mechanisms is necessary in future.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords