Effects of Quercetin Induced Cell Death on a Novel Gene "URG4/URGCP" Expression in Leukemia CellsYavuz Dodurga1*, Cigir Biray Avci2, Lale Satiroglu-Tufan N3, Sunde Yilmaz Susluer2, Ozlem Dogan Sigva Z2, Guray Saydam4 and Cumhur Gunduz
- *Corresponding Author:
- Dr. Yavuz Dodurga
Department of Medical Biology
Kinikli Kampüsü Morfoloji Binasi Kat:3
Kinikli / Denizli, Turkey
Tel: +90 258 296 25 34
Fax: +90 258 296 24 33 17 65
E-mail: [email protected]
Received date: November 28, 2011; Accepted date: December 26, 2011; Published date: December 28, 2011
Citation: Dodurga Y, Avci CB, Lale Satiroglu-Tufan N, Susluer SY, Ozlem Dogan Sigva Z, et al. (2012) Effects of Quercetin Induced Cell Death on a Novel Gene "URG4/URGCP" Expression in Leukemia Cells. J Cancer Sci Ther 4: 006-009. doi: 10.4172/1948-5956.1000102
Copyright: © 2012 Dodurga Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation ( URG4/URGCP ), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL–60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment.