alexa
Reach Us +44-1647-403003
Effects of Quercetin Induced Cell Death on a Novel Gene andquot;<em>URG4/URGCP</em>andquot; Expression in Leukemia Cells | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effects of Quercetin Induced Cell Death on a Novel Gene "URG4/URGCP" Expression in Leukemia Cells

Yavuz Dodurga1*, Cigir Biray Avci2, Lale Satiroglu-Tufan N3, Sunde Yilmaz Susluer2, Ozlem Dogan Sigva Z2, Guray Saydam4 and Cumhur Gunduz

1Pamukkale University, School of Medicine, Department of Medical Biology, Denizli

2Ege University, School of Medicine, Department of Medical Biology, Izmir

3Pamukkale University, School of Medicine, Department of Medical Genetics, Denizli

4Ege University, School of Medicine, Department of Hematology, Izmir

*Corresponding Author:
Dr. Yavuz Dodurga
Pamukkale University
Department of Medical Biology
Kinikli Kampüsü Morfoloji Binasi Kat:3
Kinikli / Denizli, Turkey
Tel: +90 258 296 25 34
Fax: +90 258 296 24 33 17 65
E-mail: [email protected]

Received date: November 28, 2011; Accepted date: December 26, 2011; Published date: December 28, 2011

Citation: Dodurga Y, Avci CB, Lale Satiroglu-Tufan N, Susluer SY, Ozlem Dogan Sigva Z, et al. (2012) Effects of Quercetin Induced Cell Death on a Novel Gene "URG4/URGCP" Expression in Leukemia Cells. J Cancer Sci Ther 4: 006-009. doi: 10.4172/1948-5956.1000102

Copyright: © 2012 Dodurga Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study aimed to investigate anti-proliferative and apoptotic effects of quercetin on human leukemia cells and effects of quercetin-induced cell death on a novel gene Up-regulated gene 4/upregulator of cell proliferation ( URG4/URGCP ), in leukemia cells. URG4/URGCP expression is determined by using RT-PCR. IC 50 of quercetin was determined as 25 microM in CCRF-CEM, HL–60 and K562 cells. In IC 50 dose group, URG4/URGCP expression was decreased 99% in HL-60 cells, 90% in CCRF-CEM cells, and 52% (24 hour) - 99% (72 hour) in K-562 cells. URG4/URGCP may play important roles in the development of leukemia, and might be a useful molecular marker for predicting the prognosis of leukemia via quercetin treatment.

 

Share This Page
Top