alexa Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats
ISSN: 2165-7939

Journal of Spine
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Research Article

Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats

Erhan Arslan1*, Ertugrul Cakir2 and Murat Selcuk Eminagaoglu3
1Department of Neurosurgery, School of Medicine, Giresun University, Giresun, Turkey
2Department of Neurosurgery, School of Medicine, Karadeniz Technical University, Trabzon, Turkey
3Department of Biochemistry, Ozel Medline Hospital, PC: 26061, Eskisehir, Turkey
Corresponding Author : Erhan Arslan, MD
Department of Neurosurgery
School of Medicine, Giresun University
Nizamiye Mah. Mumcular Sok. No: 1/1
PC:28000, Merkez/Giresun, Turkey
Tel: +(90)4543101690
Fax: +(90)4543101696
E-mail: [email protected]
Received April 11, 2014; Accepted May 23, 2014; Published May 28, 2014
Citation: Arslan E, Cakir E and Eminagaoglu MS (2014) Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats. J Spine 3:167. doi:10.4172/2165-7939.1000167
Copyright: © 2014 Arslan E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: The effect of rifampisin was examined using a spinal cord ischemia/reperfusion (I/R) injury model in rats.

Materials and Methods: 25 Wistar Albino rats weighing 200-250 g were used for the study. Rats were divided in 5 groups. After laparatomy, aorta was clamped 45 minutes below the left renal artery in all groups except shamoperated group. 1 cc saline was injected to vehicle group and rifampicin (20 mg/kg) was administered to treatment group intraperitoneally. In group 5, 20 mg/kg of rifampicin applied intraperitoneally before laparotomy. 2 hours after application of rifampicin, the animals underwent clip compression for 45 minutes after exposure of the abdominal aorta. At 1 h and 24 h, all groups were examined for neurologic outcome according to Tarlov scale. At 24 h, rats were sacrificed. The spinal cord was excised by laminectomy between the T8-12 levels and tissue MDA levels were studied.

Results: At 1 h, difference between motor scores of sham-operated group and other groups was statistically significant (P=0.008). At 24 h, difference between trauma and treatment or p-treatment group was statistically significant (P<0.05). When MDA levels of the groups were compared by using Kruskal Wallis variance analysis, the result was statistically significant (P=0.001). When trauma and vehicle group were compared with treatment group by Mann Whitney U test, the results were statistically significant (P=0.008).

Conclusions: To our knowledge, this is the first study that shows the effects of rifampicin on spinal cord ischemia/reperfusion injury. Rifampicin was found to be effective on spinal cord ischemia/reperfusion injury, but further investigations are mandatory.

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