Effects of Selective Neonatal Amygdala Damage on Concurrent Discrimination Learning and Reinforcer Devaluation in Monkeys
Kazama AM* and Bachevalier J
Yerkes National Primate Research Center and Department of Psychology, Emory University, Atlanta, GA, USA
- Corresponding Author:
- Kazama AM
Yerkes National Primate Research Center and Department of Psychology
Emory University, 954 Gatewood Rd. Atlanta, GA 30329, USA
E-mail: [email protected]
Received date: July 05, 2013; Accepted date: August 17, 2013; Published date: August 27, 2013
Citation: Kazama AM, Bachevalier J (2013) Effects of Selective Neonatal Amygdala Damage on Concurrent Discrimination Learning and Reinforcer Devaluation in Monkeys. J Psychol Psychother S7:005. doi:10.4172/2161-0487.S7-005
Copyright: © 2013 Kazama AM et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: The amygdala is known to be a key neural structure in many neuropsychiatric disorders. Primarily known for its involvement in fear regulation, the amygdala also plays a critical role in appetitive flexible decisionmaking. Yet, its contribution to the development of flexible goal-directed behavior has not been thoroughly examined.
Design: The current study examined flexible decision-making abilities after neonatal amygdala lesions in nonhuman primates using a behavioral paradigm known to measure the flexible monitoring of goal-directed choices in rodents, monkeys, and humans.
Method: Rhesus monkeys of both sexes were divided into two groups, a sham-operated control group (N=4) and a group with neonatal neurotoxic amygdala lesions (N=5). Animals received the lesions at 1-2 weeks and were tested at both four and six years of age on a concurrent discrimination reinforcer devaluation task.
Results: Although neonatal amygdala damage spared learning stimulus-reward associations, it severely impaired the ability to flexibly shift object choices away from those items associated with devalued food rewards. The results were similar to those obtained in monkeys that had acquired the same lesions in adulthood.
Conclusions: Thus, the amygdala is critical for appetitive decision-making, and provide further evidence of little functional sparing after early amygdala insult. The findings are discussed in relation to other behavioral measures on the same animals and to clinical neuropsychiatric disorders.