alexa Effects of Si(IV) Released from Chitosan-Silicate Hybrids on Proliferation and Differentiation of MG63 Osteoblast Cells

Bioceramics Development and Applications
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Research Article

Effects of Si(IV) Released from Chitosan-Silicate Hybrids on Proliferation and Differentiation of MG63 Osteoblast Cells

Y. Shirosaki1* K. Tsuru2 S. Hayakawa1,3 Y. Nakamura4 I. R. Gibson5,6 and A. Osaka1,3

1Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

2Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan

3Research Center of for Biomedical Engineering, Okayama University, Okayama 700-8530, Japan

4Faculty of Engineering, Okayama University, Okayama 700-8530, Japan

5Institute of Medical Sciences, Aberdeen University, Aberdeen AB25 2ZD, UK

6Department of Chemistry, Aberdeen University, Aberdeen AB24 3UE, UK

Corresponding Author:
Y. Shirosaki,
E-mail: [email protected]

Received date: November 11, 2010; Accepted date: December 02, 2010



Chitosan-?-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by a sol-gel method. Effects of Si(IV) released from them on proliferation and differentiation were examined in terms of cell metabolic activity and alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. Released Si(IV) inhibited cell proliferation, while it promoted cell differentiation. Thus, osteocompatibility of the chitosan hybrid membranes can be controlled due to the amount of Si(IV) released from them as the hybrids in the system chitosan-GPTMS-TEOS are applied for cell culture.


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