alexa Effects of Space Flight on the Expression of Liver Proteins in the Mouse | OMICS International | Abstract
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Journal of Proteomics & Bioinformatics
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Research Article

Effects of Space Flight on the Expression of Liver Proteins in the Mouse

Daila S. Gridley1,2, Michael J. Pecaut1,2, Lora M. Green1, E. Clifford Herrmann2, Brandon Bianski1, James M. Slater1, Louis S. Stodieck4, Virginia L. Ferguson4 and Lawrence B. Sandberg2,3*

1Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA

2Department of Basic Sciences, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA

3Department of Rheumatology, Pathology and Human Anatomy, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA

4Department of Aerospace Engineering, Bioserve Space Technologies, University of Colorado, Boulder, CO 80309, USA

*Corresponding Author:
Lawrence B. Sandberg
Department of Basic Sciences
Loma Linda University
MT 231, 11085 Campus Street
Loma Linda, California 92354, USA
Tel: 909-558-4527
Fax: 909-558-4887
E-mail: [email protected]

Received Date: October 05, 2012; Accepted Date: October 27, 2012; Published Date: October 30, 2012

Citation: Gridley DS, Pecaut MJ, Green LM, Herrmann EC, Bianski B, et al. (2012) Effects of Space Flight on the Expression of Liver Proteins in the Mouse. J Proteomics Bioinform 5: 256-261. doi: 10.4172/jpb.1000246

Copyright: © 2012 Gridley DS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Raw data derived from mass spectroscopic (MS) analyses of formalin-fixed paraffin-embedded (FFPE) tissue sections of the essential metabolic organ, liver, allocated by the provider (Amgen) from mice subjected to 13 days of microgravity on NASA Flight STS-118 were analyzed by two different search engines, using shotgun proteomics. With the eight statistically significant readouts in hand, Ingenuity Pathway Analysis (IPA) was employed to visualize probable biologic pathway relationships among proteins that might be associated with alterations in liver biochemistry due to space flight. Most noteworthy was the finding of up-regulation of the first urea cycle enzyme carbamoylphosphate synthetase, consistent with increased amino acid catabolism resulting from gravitational changes, and/ or other stress associated with missions in space. Down-regulation of fructose-bisphosphate aldolase B, regucalcin, ribonuclease UK114, alpha enolase, glycine N-methyltransferase and S-adenosyl methionine synthetase isoform type-1 was observed. 60 kDa heat shock protein was elevated.

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