Effects of Subacute and Subchronic Treatment of Synthetic Plant Growth Regulators on Liver Damage Serum Biomarkers Tissue Antioxidant Defense Systems and Lipid Peroxidation in RatsNecati Ozok and Ismail Celik*
Science Faculty, Biology Department, Yuzuncu Yil University, Van, Turkey
- *Corresponding Author:
- Ismail Celik
Science Faculty, Biology Department
Yuzuncu Yil University, 65080 Van, Turkey
Tel: +90. 432. 2251704-2278
Fax: +90. 432. 2251114
E-mail: [email protected], [email protected]
Received Date: January 08, 2012; Accepted Date: April 21, 2012; Published Date: April 23, 2012
Citation: Ozok N, Celik I (2012) Effects of Subacute and Subchronic Treatment of Synthetic Plant Growth Regulators on Liver Damage Serum Biomarkers Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats. J Drug Metab Toxicol 3:124. doi: 10.4172/2157-7609.1000124
Copyright: © 2012 Ozok N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study was aimed to investigate the effects of some synthetic plant growth regulators; ß-Naphthoxy acetic acid (ß-NOA) and 4-Chlorophenoxy acetic acid (4-CPA) at 10 and 20 ppm dosages on liver damage, antioxidant defense system and lipid peroxidation in rats. Rats were divided into 12 groups as control, ß-NOA and 4-CPA at 10 and 20 ppm dosages application groups. Serum marker enzymes and biochemical parameters were selected as biomarkers for liver damage. Antioxidant defense systems as SOD, GR, CAT, GSH-Px, GST and G6PD enzyme activities and GSH and MDA contents were determined in tissues as the indicators of oxidative stress. At the end of experiments, the statistically significant changes were observed in the levels of TPRO, TALB, TCHOL, TBIL, AST, ALT and LDH as liver damage serum biomarkers in rats exposed to 10 and 20 ppm of ß-NOA and 4-CPA as compared with controls. MDA levels increased in all the tissues of rats exposed to ß-NOA and 4-CPA dosages whereas the fluctuation in SOD, GR, CAT, GSH-Px, GST and G6PD enzyme activities and GSH levels were observed compared with controls. It could be concluded that the treatments of ß-NOA and 4-CPA dosages may induce liver damage and oxidative stress.