alexa Effects of the CPAP Treatment on the NON-REM Sleep Micr
ISSN: 2167-0277

Journal of Sleep Disorders & Therapy
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Research Article

Effects of the CPAP Treatment on the NON-REM Sleep Microstructures in Patients with Severe Apnea-Hypoapnea Syndrome

Marcela Smurra1, Susana Blanco2*, Veronica Eguiguren1 and Cecilia DiRisio3
1Hospital Tornú, Argentina
2Faculty of Engineering, University of Belgrano-CONICET, Argentina
3Dosimetry Laboratory and Medical Technology, Faculty of Engineering, University of Belgrano, Argentina
Corresponding Author : Susana Blanco
Faculty of Engineering
University of Belgrano-CONICET
Villanueva 1324, Buenos Aires, Argentina
Tel: 54-911556-7434
E-mail: [email protected]
Received March 04, 2014; Accepted March 24, 2014; Published March 26, 2014
Citation: Smurra M, Blanco S, Eguiguren V, DiRisio C (2014) Effects of the CPAP Treatment on the NON-REM Sleep Microstructures in Patients with Severe Apnea-Hypoapnea Syndrome. J Sleep Disord Ther 3:161 doi:10.4172/2167-0277.1000161
Copyright: © 2014 Smurra M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Sleep quality is affected in patients with sleep apnea- hypopnea syndrome (SAHS) with nocturnal and diurnal
consequences. Most of these patients who are treated with positive airway pressure (CPAP) return to normal sleep
patterns. We could consider good sleepers those patients who present more sleep spindles in stage II, and slower
wave sleep as a good sign of better sleep quality.
The objective in this research study was to compare the microstructure of stage II using the number of spindles
and the increase of slow wave sleep before and after CPAP night titration.
We developed a wavelet filter using a spline cubic function from a wavelet mother, which was appropriate to
be used over electroencephalographic signal. By means of this filter in a multi-resolution mode, the spindles were
detected from the increase of the IV band power; the sampling rate of the device determined the filter characteristics.
The staging of polysomnographic studies was made by an expert according AASM (American Academy of Sleep
Medicine) and then processed by the filter to get the index of sleep spindles before-and-after CPAP during stage
II as well as the relationship between fast and slow powers from the EEG signal. An increase in the power of the
slow waves vs. fast activity was observed in all the cases as a feature of better sleep. The neuroprotective effect
described in previous research works regarding the density of the sleep spindles seems to be detected in patients
improving their sleep quality after the correction of the apnea-hypopnea syndrome using CPAP.

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