Effects of the Maternal Hypertension in Renal Development in Offspring of Rats
|Sonia Regina Jurado*|
|Federal University of Mato Grosso do Sul, Brazil|
|Corresponding Author :||Sonia Regina Jurado
Federal University of Mato Grosso do Sul P.O.Box
210, Avenue Ranulpho Marquês Leal, 3484, Zip code 79620-080
Três Lagoas, Mato Grosso do Sul, Brazil
Tel: +55 67-3509-3714
E-mail: [email protected]
|Received March 20, 2014; Accepted April 25, 2014; Published May 05, 2014|
|Citation: Jurado SR (2014) Effects of the Maternal Hypertension in Renal Development in Offspring of Rats. J Clin Exp Cardiolog 5: 306. doi:10.4172/2155-9880.1000306|
|Copyright: © 2014 Jurado SR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: As nephrogenesis takes place entirely before term birth and many factors may have an impact on kidney development and reduce nephron numbers. The objective of the study was to analyze the effect of hypertension during pregnancy on glomeruli and microvasculature of the kidneys in fetal and neonates.
Methods: Total nine sub-groups allocated from 3 main groups of fetuses (20th d) and newborns (2nd and 15th d) offspring’s from normotensive mothers (C), SHR and L-NAME were performed. Glomerular area and the number of glomeruli per area were determined per animal in 25 random fields of the right kidney. Also, it has assessed the thickness of tunica media of renal microvessels.
Results: Nephrons number was lower in L-NAME (2.18 ± 0.82; 2.18 ± 0.73) group compared to C (2.51 ± 0.83; 2.71 ± 0.79) at 2nd and 15th d, respectively. Glomerular area in hypertensives (L-NAME: 1.80 ± 0.46; 1.91 ± 0.44 and SHR: 1.70 ± 0.47; 1.53 ± 0.42 at 2nd and 15th d, respectively) were smaller than C (1.83 ± 0.62 and 2.17 ± 0.61, at 2nd and 15th d, respectively). Thickening of the media of arterioles was found in hypertensive animals at 2nd and 15th d compared to C.
Conclusion: Maternal hypertension causes impaired renal development which potentially may lead to hypertension in later life.