alexa Effects of Toothpaste on the Gingival Barrier Function in vitro
ISSN: 2247-2452

Oral Health and Dental Management
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effects of Toothpaste on the Gingival Barrier Function in vitro

 
To read the full article Peer-reviewed Article PDF image

Abstract

Introduction: Toothpastes (TPs) routinely contain detergents for their emulsifying and foaming properties. The most common detergent sodium lauryl sulfate (SLS) displays irritant effects to skin. Studies suggested that it may also affect the structural integrity of the oral mucosa. Besides detergents protective substances may also be ingredients of toothpastes. The aim of this study was to investigate the effect of different toothpastes on the gingival epithelial barrier function. Materials and methods: Immortalised human gingival keratinocytes (IHGK) were seeded on ThinCert™ cell culture inserts. Slurries from 4 different TPs were applied apically to the cells (1:100 and 1:1000 diluted). One TP contained additionally triclosan, one herbal extracts and one zinc citrate. The Transepithelial Electrical Resistance (TER) was measured hourly (h) until 8h and after 24, 48 and 72h. The cytotoxicity of the slurries was investigated by Lactate Dehydrogenase (LDH) release. Results: All TP slurries in 1:100 dilution caused a decrease of the TER until 8h (8-13 Ohm x cm2) (p < 0.05). The most distinct decrease was observed using the TP without additional components. The 1:1000 dilution of the TP induced a TER increase (5-13 Ohm x cm2 ) after 48 and 72h (p < 0.05). The most distinct increase was induced by a TP containing zinc. No significant cytotoxic effect caused by TPs was observed. Conclusions: The results of this study showed that TP slurries dose-dependently modulated the gingival barrier function without increased cytotoxicity. High dilutions showed TER enhancing, lower dilutions TER impairing properties. The decreasing effect was reduced by active ingredients like zinc.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords