alexa Effects of Ultraviolet Exposure Behaviors on Skin Pigmentation and Melanoma
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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Effects of Ultraviolet Exposure Behaviors on Skin Pigmentation and Melanoma

Elena B Hawryluk1*, Asli Oztan2 and David E Fisher3
1Dermatology Program, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
2F. M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Corresponding Author : Elena B Hawryluk
Dermatology Program, Boston Children’s Hospital
Harvard Medical School, Boston, Massachusetts, USA
Tel: 617-643-5428
E-mail: [email protected]
Received May 15, 2014; Accepted June 20, 2014; Published June 22, 2014
Citation: Hawryluk EB, Oztan A, Fisher DE (2014) Effects of Ultraviolet Exposure Behaviors on Skin Pigmentation and Melanoma. Pigmentary Disorders 1:113. doi:10.4172/2376-0427.1000113
Copyright: © 2014 Hawryluk EB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Tanning refers to the practice of darkening the pigment of one's skin through exposure to natural sunlight or artificial Ultraviolet (UV) radiation. Studies have explored the molecular mechanism of tanning induced by UV radiation exposure. UV radiation triggers DNA damage in the nucleus of keratinocytes, which induces production of melanin by melanocytes. The melanin is then transported to keratinocytes and manifests as darker pigmentation. An increasing amount of data accumulate to support a role for UV exposure in the development of both melanoma and non-melanoma skin cancers. This article reviews the body of literature reporting the effects of UV exposure on melanocyte biology, skin pigmentation, and melanoma

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