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Short Communication

Effects of VEGF on Bone Cells Metabolism and Activity

Yang Y1*, Chai L2, Liao C1 and Qu JY3

1Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China

2School of Dentistry, University of Queensland, Brisbane, Australia

3Biomedical Engineering Program, Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong SAR, China

*Corresponding Author:
Dr. Yang Yan-Qi BDS
MOrthRCS (Edin), PhD, FDS RCS (Edin)
Assistant Professor, Faculty of Dentistry
The University of Hong Kong
The Prince Philip Dental Hospital
34 Hospital Road, Hong Kong
Tel:(852) 2859 0252
Fax:(852) 2559 3803
E-mail: [email protected]

Received date: April 01, 2014; Accepted date: July 14, 2014; Published date: July 16, 2014

Citation: Yang Y, Chai L, Liao C, Qu JY (2014) Effects of VEGF on Bone Cells’ Metabolism and Activity. Dentistry 4:247. doi: 10.4172/2161-1122.1000247

Copyright: © 2014 Yang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


The treatments of bone loss have been extended to the molecular level and previous research has found that vascular endothelia growth factor (VEGF) can enhance the vascular network building around bone injury to aid healing progress. In this manuscript, we discussed the effects of VEGF on bone cells’ metabolism and activity. VEGF could enhance osteogenesis by inducing neovascularization and direct effects on bone cells via regulation on genes osteoprotegerin (OPG)/the receptor activator of nuclear factor kappa beta ligand (RANKL), alkaline phosphatase (ALP), osteopontin (OPN) and osteocalcin (OCN), without causing abnormal cell metabolism, which may shed lights on new clinical treatments of bone loss.


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