alexa Efficacy and Safety of Amtolmetin Guacyl in the Management of Knee Osteoarthritis and Associated Dyspepsia in Routine Clinic Setting: AGATA Study | OMICS International
ISSN: 2161-0533

Orthopedic & Muscular System: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Efficacy and Safety of Amtolmetin Guacyl in the Management of Knee Osteoarthritis and Associated Dyspepsia in Routine Clinic Setting: AGATA Study

Nasonov Evgeniy Lvovich1, Denisov Lev Nikolaevich1,Tsvetkova Elena Sergeevna1, Otteva Elvira Nikolaevna2, Dubikov Alekzander Ivanovich3, Yakupova Svetlana Petrovna4, Ivanova Olga Nikolaevna5, Korshunov Nikolay Ivanovich6, Vaisberg Alexsandra Rudolfovn7, Abishev Rashad Azadovich8, Tartinov Anton Vladimirovich9, Amit Garg10, Suhas Khandarkar10, Namita Gupta10, Shyam Akku10*

1V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

2Territorial Clinical Hospital One, Institute for Postgraduate Training of Healthcare Specialists, Khabarovsk

3Pacific State Medical University, Ministry of Health of Russia, Vladivostok, Russia

4Kazan State Medical University, Ministry of Health of the Russian Federation1

5Voronezh Regional Clinical Hospital One, Voronezh, Russia

6Regional Clinical Hospital" State Health Care Institution, Yaroslavl, Russia

7Department of Internal Medicine, State Medical Academy, Nizhny Novgorod

8St. Petersburg State Budgetary Healthcare Institution "City polyclinic No 100 Nevsky district of St. Petersburg

9Limited Liability Company "Regional Medical and Diagnostic Center", Novosibirsk

10Dr Reddy’s Laboratories Ltd. Hyderabad, India

*Corresponding Author:
Shyam Akku
Associate Director-GMA
Dr Reddy’s Laboratories Ltd., Hyderabad, India
Tel: +91-40-49002399
E-mail: [email protected]

Received Date: March 13, 2017; Accepted Date: April 24, 2017; Published Date: April 30, 2017

Citation: Nasonov EL, Denisov LN, Tsvetkova ES, Otteva EN, Dubikov AI et.al. (2017) Efficacy and Safety of Amtolmetin Guacyl in the Management of Knee Osteoarthritis and Associated Dyspepsia in Routine Clinic Setting: AGATA Study. Orthop Muscular Syst 6: 233. doi:10.4172/2161-0533.1000233

Copyright: © 2017 Nasonov EL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: To evaluate the efficacy and safety of amtolmetin guacyl in the management of osteoarthritis (OA) of knee and associated dyspepsia in routine clinic setting. Methods: In an observational study conducted in the OA outpatients between February 2015 and December 2015, patients with knee joint (KJ) pain ≥ 40 mm on visual analogue scale (VAS) and dyspepsia were enrolled. Amtolmetin guacyl 600 mg tablets twice daily was administered for up to 28 days. Patients were evaluated at baseline, Day 14 ± 3, and at Day 28 ± 3 for severity of pain in “target” knee (VAS), Western Ontario and Mc master Universities Arthritis (WOMAC) pain and stiffness, and severity of dyspepsia assessment (SODA). Results: Of the 219 OA patients, approximately 72.5% patients reported decrease in pain in the target KJ by ≥ 40% at the end of the study. Mean pain reduced from 65 mm at baseline to 27 mm at the end of the study. A significant decrease in WOMAC pain score, morning stiffness, and functional limitations were also observed (P<0.001). A significant decrease in severity of dyspepsia assessment (SODA) score and increase in satisfaction was observed. Amtolmetin tolerability was comparatively better than previously used NSAIDS. Conclusion: Amtolmetin guacyl is effective and safe in OA patients with associated dyspepsia and has comparatively better tolerability than other NSAIDS. This trial is registered with https://clinicaltrials.gov, number NCT02865161.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version