alexa Efficacy and Safety of Progesterone versus Magnesium Sulfate in the Management of Preterm Labor: A Randomized Study | OMICS International | Abstract
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Efficacy and Safety of Progesterone versus Magnesium Sulfate in the Management of Preterm Labor: A Randomized Study

Batool Teimoori1, Nahid Sakhavar1, Masoome Mirteimoori1, Behzad Narouie2,*, Mohammad Ghasemi-rad3, Mehrnaz Sarooneh-rigi1 and Shahin Navvabi-rigi4

,1Dept. of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

2Researcher of Clinical Research Development Center, Ali-ebne-Abitaleb Hospital, Zahedan 3University of Medical Sciences, Zahedan, Iran

3Genius and Talented Student Organization, Student Research Committee (SRC), Urmia University of Medical Sciences, Urmia, Iran

4Promotion Health Center,Zahdan University of Medical Sciences, Zahedan, Iran

*Corresponding Author:
Behzad Narouie
Researcher of Clinical Research Development Center
Ali-ebne-Abitaleb Hospital
Zahedan University of Medical Sciences
Zahedan, Iran
Tel: +989155434493
Fax: +985413414103
E-mail: [email protected]

Received Date: August 08, 2011; Accepted Date: November 07, 2011; Published Date: November 18, 2011

Citation: Teimoori B, Sakhavar N, Mirteimoori M, Narouie B, Ghasemi-rad M, et al. (2011) Efficacy and Safety of Progesterone versus Magnesium Sulfate in the Management of Preterm Labor: A Randomized Study. Gynecol Obstetric 1:105. doi: 10.4172/2161-0932.1000105

Copyright: © 2011 Teimoori B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Preterm labor is the leading cause of prenatal and neonatal mortality morbidity and long term neurodevelopmental problems.so that different treatments have been employed in order to suppress preterm labor from several years ago. Magnesium sulfate is often used as first line in suppressing of preterm labor. Side effect of this : thirst, hyperthermia, headache, diplopia, respiratory depression and rare cases respiratory paralysis and arrest.In later pregnancy progesterone may be important in maintaining uterine quiescence by limiting the production of stimulatory prostaglandins and inhibiting the expression of contraction – associated protein genes with in the myometrium natural progesterone administrated vaginally is considered is effective in suppression of preterm birth and safe for both mother and fetus. We take a decision that compare the ability of magnesium sulfate with progesterone in suppression of preterm labor.

Methods: In this randomized clinical trial 132 cases were chosen form pregnant women between the 26-34 weeks of pregnancy who were suffering from preterm contractions of uterus with intact amniotic sac and cervical dilatation of less than 4cm.these women had referred to obstetric ward of Ali – Ebne – Abitalib hospital, Zahedan, during the years of 2008-9 and randomly were `divided into two equal groups (66 cases in each group). The results were analyzed by chi square and T test with spss software.

Results: In first group primarily 4 grams of magnesium sulfate infused. And then 10 grams (2grams per hours) was continued.in second group progesterone used 200 mg vaginal suppository as single dose.in first group delivery during 48 hour was failure of treatment and second group if no controlled contraction of uterus after 1 hour, changed to magnesium sulfate and this case was failured. From 66 women in magnesium sulfate group in 58 case (89%) suppressed delivery at least for 48 hours.In second group from 66 women 52 case (79%) suppressed delivery at least for 48 hours.in this study differentiation was no significant (p value=0.161) in two group. 95 percent women in first group (magnesium sulfate) had side effects and 5 percent women progesterone group had involved with side effects.

Conclusion: This finding show the ability of progesterone in suppression of preterm labor is similar to magnesium sulfate however maternal side effect of magnesium sulfate was 95% while it was no for progesterone.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7