alexa Efficacy of Combination Therapy with rhTNFR:Fc and Meth
ISSN: 2167-7921

Journal of Arthritis
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Research Article

Efficacy of Combination Therapy with rhTNFR:Fc and Methotrexate in the Patients with Disease-modifying Antirheumatic Drug -resistant Rheumatoid Arthritis

Fu Wen-yi, Zhang Ning* and Yang Lili
Department of Rheumatology, Shengjing Hospital, China Medical University, Shengyang 110004, China
Corresponding Author : Zhang Ning
Department of Rheumatology
Shengjing Hospital
China Medical University
Shengyang 110004, China
E-mail: [email protected]
Received March 14, 2012; Accepted April 20, 2012; Published April 22, 2012
Citation: Wen-yi F, Ning Z, Lili Y (2012) Efficacy of Combination Therapy with rhTNFR:Fc and Methotrexate in the Patients with Disease-modifying Antirheumatic Drug -resistant Rheumatoid Arthritis. J Arthritis 1:104. doi:10.4172/2167-7921.1000104
Copyright: © 2012 Wen-yi F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: To observe the efficacy of combining recombinant human tumour necrosis factor-Fc [rhTNFR:Fc ,etanercept] and methotrexate (MTX) in patients with disease-modifying antirheumatic drug (DMARD)-resistant rheumatoid arthritis.

Methods: Collected 64 active RA patients with DMARD-resistant, according to patients’ gender, age, duration and extent of disease activity, divided the 64 patients randomly into comparable two groups. The experimental group within thirty-two patients, were treated with twice-weekly subcutaneous etanercept (25 mg) and meanwhile weekly oral MTX (15 mg);the control group within thirty-two patients, were treated with daily oral prednisone (5-10 mg) and meanwhile weekly oral MTX (15 mg).Course of treatment is 12 weeks. Clinical response was assessed using American College of Rheumatology (ACR) criteria.

As compared with patients received prednisone and MTX, patients received etanercept and MTX had a more significant improvement at ACR20 at 4th, 8th and 12th weeks (P<0.05), and a more significant improvement at ACR50 at 4th, 8th and 12th weeks (P<0.05).

Conclusions: Compared to the traditional combination of MTX and low dose prednisone, etanercept combining MTX has a more significant efficacy in patients with DMARD-resistant rheumatoid arthritis.


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