alexa Efficacy of Dendritic Cell-Based Cancer Immunotherapy
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
Open Access

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Perspective Article

Efficacy of Dendritic Cell-Based Cancer Immunotherapy

Shigetaka Shimodaira1*, Yumiko Higuchi1, Ryu Yanagisawa1, Masato Okamoto2 and Shigeo Koido3

1Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Japan

2Department of Advanced Immunotherapeutics, Kitasato University School of Pharmacy, Japan

3Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Japan

*Corresponding Author:
Shigetaka Shimodaira
Center for Advanced Cell Therapy
Shinshu University Hospital
Matsumoto, Japan
Tel: +81-263-37-3580
Fax: +81-263- 37-3580
E-mail: [email protected]

Received Date: January 16, 2016; Accepted Date: January 25, 2016; Published Date: January 28, 2016

Citation: Shimodaira S, Higuchi Y, Yanagisawa R, Okamoto M, Koido S (2016) Efficacy of Dendritic Cell-Based Cancer Immunotherapy. Biochem Anal Biochem 5:240. doi:10.4172/2161-1009.1000240

Copyright: © 2016 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Dendritic cells (DCs) have antigen-specific bioactivity against tumor-associated antigens. The acquisition of tumor immunity with DC vaccination could be determined using both tetramer analysis and interferon γ-producing clones in enzyme-linked immunosorbent spot assays. A combination of DC vaccination with low-dose metronomic therapy and chemoradiotherapy would contribute to an enhanced acquired immunity for cancer therapy. The efficacy of DC vaccination may provide a survival benefit in some patients with cancer by achieving a prolonged quality-adjusted life year.

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