Efficacy of Dobesilate in Allergic Rhinitis - Case ReportPedro Cuevas1*, Miguel Hinojosa2, Javier Angulo1 and Guillermo Giménez-Gallego3
- *Corresponding Author:
- Pedro Cuevas
Facultad de Medicina
Universidad Alfonso X el Sabio
Villanueva de la Cañada
E-mail: [email protected]
Received date: September 24, 2015; Accepted date: October 26, 2015; Published date November 02, 2015
Citation: Cuevas P, Hinojosa M, Angulo J, Giménez-Gallego G (2015) Efficacy of Dobesilate in Allergic Rhinitis - Case Report. J Develop Drugs 4:139. doi:10.4172/2329-6631.1000139
Copyright: © 2015 Cuevas P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Allergic rhinitis is a common condition that causes a negative effect on patient well-being. Antihistamines and glucocorticoids, the first line treatments usually administered for rhinitis, are normally associated to side effects. In addition, they may show limited efficiency in controlling nasal obstruction, edema and hyperemia occurring secondary to persistent inflammation. Dobesilate, an inhibitor of fibroblast growth factor and vascular endothelial growth factor, shows a markedly anti-inflammatory activity in several inflammation-dependent diseases and inflammation models. Our study shows that nostril spray application of dobesilate for one week is effective in reducing symptoms and signs in patients with seasonal allergic rhinitis.