alexa Efficacy of Dobesilate in Allergic Rhinitis - Case Report | OMICS International | Abstract
ISSN: 2329-6631

Journal of Developing Drugs
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Case Report

Efficacy of Dobesilate in Allergic Rhinitis - Case Report

Pedro Cuevas1*, Miguel Hinojosa2, Javier Angulo1 and Guillermo Giménez-Gallego3

1Facultad de Medicina, Universidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, Spain

2Hospital Universitario Ramón y Cajal, Ctra. de Colmenar Viejo, Km. 9,100, 28034 Madrid, Spain

3Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

*Corresponding Author:
Pedro Cuevas
Facultad de Medicina
Universidad Alfonso X el Sabio
Villanueva de la Cañada
Madrid, Spain
Tel: (0034)913738458
E-mail: [email protected]

Received date: September 24, 2015; Accepted date: October 26, 2015; Published date November 02, 2015

Citation: Cuevas P, Hinojosa M, Angulo J, Giménez-Gallego G (2015) Efficacy of Dobesilate in Allergic Rhinitis - Case Report. J Develop Drugs 4:139. doi:10.4172/2329-6631.1000139

Copyright: © 2015 Cuevas P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Allergic rhinitis is a common condition that causes a negative effect on patient well-being. Antihistamines and glucocorticoids, the first line treatments usually administered for rhinitis, are normally associated to side effects. In addition, they may show limited efficiency in controlling nasal obstruction, edema and hyperemia occurring secondary to persistent inflammation. Dobesilate, an inhibitor of fibroblast growth factor and vascular endothelial growth factor, shows a markedly anti-inflammatory activity in several inflammation-dependent diseases and inflammation models. Our study shows that nostril spray application of dobesilate for one week is effective in reducing symptoms and signs in patients with seasonal allergic rhinitis.

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