alexa Efficacy of Frovatriptan vs. Other Triptans in Weekend Migraine: Pooled Analysis of Three Double-Blind, Randomized, Crossover, Multicenter Studies | OMICS International
ISSN: 2168-975X

Brain Disorders & Therapy
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Research Article

Efficacy of Frovatriptan vs. Other Triptans in Weekend Migraine: Pooled Analysis of Three Double-Blind, Randomized, Crossover, Multicenter Studies

Carlo Lisotto1*, Lidia Savi2, Lorenzo Pinessi2, Mario Guidotti3, Stefano Omboni4 and Giorgio Zanchin5
1Department of Neurology, Azienda Ospedaliera Santa Maria degli Angeli, Pordenone, Italy
2Neurology II, Headache Center, Department of Neurosciences, University of Turin, Italy
3Department of Neurology, Valduce Hospital, Como, Italy
4Italian Institute of Telemedicine, Varese, Italy
5Headache Center, Department of Neurosciences, University of Padua, Italy
Corresponding Author : Dr. Carlo Lisotto
Headache Center, Department of Neurology
Azienda Ospedaliera Santa Maria degli Angeli
Via Montereale 24, 33170 Pordenone, Italy
Tel: +390434841420
Fax: +390434841611
E-mail: [email protected]
Received April 15, 2014; Accepted May 22, 2014; Published May 29, 2014
Citation: Lisotto C, Savi L, Pinessi L, Guidotti M, Omboni S, et al. (2014) Efficacy of Frovatriptan vs. Other Triptans in Weekend Migraine: Pooled Analysis of Three Double-Blind, Randomized, Crossover, Multicenter Studies. Brain Disord Ther 3:128. doi:10.4172/2168-975X.1000128
Copyright: © 2014 Lisotto C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Migraine attacks usually occur at any time, in particular either during days off or workdays. Limited evidence is available on the efficacy of antimigraine drugs in patients whose attacks occur on weekends. Objective: To evaluate the efficacy of four different triptans in weekend vs. workday migraine attacks through a pooled analysis of individual data of three randomized, double-blind, crossover studies. Methods: Subjects with a history of migraine with or without aura were randomized to frovatriptan 2.5 mg or rizatriptan 10 mg (study 1), frovatriptan 2.5 mg or zolmitriptan 2.5 mg (study 2), frovatriptan 2.5 mg or almotriptan 12.5 mg (study 3). Each patient was requested to treat up to 3 attacks with each drug during both 3 month periods, as established by the crossover trial protocol. In this retrospective analysis the migraine attacks occurring on workdays were differentiated from those occurring on weekends. The efficacy of the drugs during weekends and workdays was compared. Results: Of the 346 intention-to-treat population patients, 188 (54%) had migraine attacks also on weekends. Overall, a total of 569 attacks occurred during weekends and 1,281 during workdays. Proportion of pain-free at 2 hours did not significantly differ between weekend and workday attacks for frovatriptan (26% vs. 27%) as well as for comparators (34% vs. 32%). Headache relief episodes were also similarly represented between weekend and nonweekend attacks (frovatriptan: 40% vs. 42% and comparators: 49% vs. 43%, p=NS). Conversely, the relapse rate within 48 hours for weekend attacks compared to workday attacks was significantly lower with frovatriptan (17% vs. 30%, p<0.05), while this finding was not observed for comparators (weekends 34% vs. workdays 40%, p=NS). Conclusions: Our study provides the first evidence that frovatriptan represents a particularly favorable option for treating weekend migraine attacks.

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