alexa Efficacy of Intravitreal Injection of Tissue Plasminogen Activator on Improvement of Visual Acuity and Decreasing the Rate of Complications in Retinal Vein Occlusion
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Efficacy of Intravitreal Injection of Tissue Plasminogen Activator on Improvement of Visual Acuity and Decreasing the Rate of Complications in Retinal Vein Occlusion

Ahmad Mirshahi1*, Mahnaz Abdollahian1, Alireza Lashay1, Abed Namavari2, Hooshang Faghihi1 and Mahdi Nili1
1Tehran University of Medical Sciences, Farabi Eye Hospital, Eye Research Center, Iran
2Chicago University, USA
Corresponding Author : Ahmad Mirshahi
Tehran University of Medical Sciences
Farabi Eye Hospital, Eye Research Center, Iran
E-mail: [email protected]
Received February 15, 2012; Accepted June 18, 2012; Published June 21, 2012
Citation: Mirshahi A, Abdollahian M, Lashay A, Namavari A, Faghihi H, et al. (2012) Efficacy of Intravitreal Injection of Tissue Plasminogen Activator on Improvement of Visual Acuity and Decreasing the Rate of Complications in Retinal Vein Occlusion. J Clin Exp Ophthalmol 3:228. doi: 10.4172/2155-9570.1000228
Copyright: © 2012 Mirshahi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Purpose: to evaluate the effect of Intravitreal tissue plasminogen activator (r-tPA) injection on improvement of visual acuity and decreasing the rate of complications in Branch Retinal Vein Occlusion (BRVO) and ischemic Complications in Retinal Vein Occlusion (CRVO). Methods: 10 patients with BRVO and 19 patients with ischemic CRVO of recent onset (from 4 to 30 days duration) and visual acuity of <=20/50 were given 100 microgram of tPA intravitreally. Ischemia was defined as an area of nonperfusion >=10 DD for CRVO and >=5 DD for BRVO. Follow up schedule contained 6 visits : at the time of injection, and 1 week,1 month, 2months, 3months, and 6 months after. Fluorescein angiography was performed before injection and at the end of the study. Results: In ischemic CRVO group: only one eye (5.6%) developed Iris neovascularization. The mean of baseline visual acuity increased from 1.8400 LogMAR to 1.5333 LogMAR at the end of the study (p=0.009). Pearson correlation coefficient was +0.874 for initial and final measured BCVAs. 8 patients (44.4%) had doubling of visual angle (0.3 LogMAR increase in BCVA). In BRVO group: 3 patients (30%) were classified in the ischemic group and after a complete 6 month follow up none of the cases (0%) developed retinal neovascularization, vitreous hemorrhage, retinal detachment or endophthalmitis. The mean of baseline visual acuity increased from 1.0710 LogMAR to 0.6100 at the end of the study (p=0.001). Discussion: Comparison between the results of our study and natural history of RVO indicates that after injection: There was doubling of visual angle in about 10% of cases. The rate of Iris neovascularization and neovascular glaucoma was decreased to 1/6 of what occurs without treatment. Endophthalmitis, retinal detachment and vitreous hemorrhage which are known as major complications of this procedure did not occur in any of our 29 patients.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords