alexa Efficacy of Neuromodulation Therapy with Vagus Nerve Stimulator in Patients with Drug-Resistant Epilepsy on Unchanged Antiepileptic Medication Regimen for 24 Months Following the Implant | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Efficacy of Neuromodulation Therapy with Vagus Nerve Stimulator in Patients with Drug-Resistant Epilepsy on Unchanged Antiepileptic Medication Regimen for 24 Months Following the Implant

Sirichai Chayasirisobhon*, Leslie Cahan, SooHo Choi, Bruce Enos, Jane Hwang, Meei Lin, Erika Pietzsch, Jeffrey Schweitzer, Benjamin Spurgeon and Suresh Gurbani

Comprehensive Epilepsy Program, Southern California Permanente Medical Group, California, USA

Corresponding Author:
SirichaiChayasirisobhon
Department of Neurology
Kaiser Permanente Medical Center
3460 E. La Palma Avenue, Anaheim, CA, 92806, USA
Tel: 7142968147
Fax: 7146442274

Received date: November 14, 2014, Accepted date: February 06, 2015, Published date: February 12, 2015

Citation: Chayasirisobhon S, Cahan L, Choi SH, Enos B, Hwang J, et al. (2015) Efficacy of Neuromodulation Therapy with Vagus Nerve Stimulator in Patients with Drug-Resistant Epilepsy on Unchanged Antiepileptic Medication Regimen for 24 Months Following the Implant. J Neurol Neurophysiol 6:268. doi:10.4172/2155-9562.1000268

Copyright: © 2015 Chayasirisobhon S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

To establish efficacy of vagus nerve stimulation (VNS) therapy in the treatment of intractable epilepsy, we
compared outcome data from the baseline period to the maintenance period (7 to 24 months post-implant) by
calculating the mean seizure frequency at 6-month intervals (7 to 12 months - first study period, 13 to 18 months -
second study period, and 19 to 24 months - third study period), in 39 consecutive patients on unchanged antiepilepsy
drug (AED) regimen for 24 months following the VNS implant. Of the 39 patients24 (61.5%) at first study
period, 25 (64.1 %) at second study period and 25 (64.1 %) at third study period were responders (≥50% reduction
in seizures). Twenty one (53.9 %) patients were responders in all three study periods. Incremental seizure control
was seen in 15 of these 21 patients. Although 3 (7.7%), 4 (10.3 %) and 8 (20.5%) patients had a total (100%)
seizure control at first, second and third study periods respectively, no patient remained seizure-free through all 3
study periods. Seven (17.9%) patients were partial responders (≥ 50% seizure reduction in two or less study
periods). Eleven patients (28.2%) were non-responders (< 50% seizure reduction in all 3 study periods). Twenty
three patients (59%) had partial epilepsy with and without secondarily generalization and 16 patients (41%) had
primary generalized epilepsy. Eleven (47.8%) of the 23 patients with partial epilepsy and 10 (62.5%) of the 16
patients with generalized epilepsy were responders in all three study periods. We conclude that: 1) More than 60 %
of patients on unchanged AED regimen continued to be responders at 24 months following the VNS implant. 2) A
trend towards increasing responder rate with increasing duration of VNS therapy was observed.3) No major
complications or side effects requiring discontinuation of VNS therapy were noted.

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