alexa Efficacy of Sublingual Use of Ketorolac Tromethamine in
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Efficacy of Sublingual Use of Ketorolac Tromethamine in Reducing Pain During Treatment with Laser Photocoagulation in Patients with Diabetic Retinopathy Double Blind, Randomized, Sham-Controlled Study

Luiz Guilherme Azevedo de Freitas1*, Roberta Albuquerque de Azevedo Paiva2, Thais Maria Pinheiro Callou3,
Danielle de Albuquerque Carrera Araújo4, Clovis Arcoverde de Freitas Neto5, Tania Cursino de Menezes Couceiro6, Theophilo José de Freitas Neto7 and Marcos Pereira de Ávila8
1Department of Retina and Vitreous of the Hospital de Olhos Santa Luzia, Recife - PE – Brazil, Graduate student in Health Sciences by UFG - Brazil
2Physician, Instituto de Olhos Clóvis Paiva, Recife (PE), Brazil, Fellowship in Cataract of the Instituto de Olho do Recife, Recife - PE - Brazil
3Fellowship in Refractive Surgery of the Universidade de São Paulo, São Paulo - Brazil
4Physician, Hospital de Olhos Santa Luzia/Santa Lucia Foundation, Switzerland
5Department of Retina and Vitreous of the Hospital de Olhos Santa Luzia, Recife - PE – Brazil, Fellowship in Ocular Immunology of the Massachusetts Eye Research and Surgery Institution, Cambridge-MA
6Master of Neuropsychiatry and Behavioral Science UFPE - Brazil
7Head of the Retina Department of the Hospital de Olhos Santa Luzia/ Santa Lucia Foundation, Brazil
8Full Professor of Ophthalmology, Head of the Retina Department UFG/CBV/CBCO, Brazil
Corresponding Author : Luiz Guilherme Freitas, MD
Ophthalmologist and Retina and Vitreous specialist
Hospital de Olhos Santa Luzia/ Funda'c ~ ao Santa Luzia
Road Pipeline 909, Eye Hospital Santa Luzia, PE Brazil
Tel: 558197354140;
E-mail: [email protected]
Received: July 29, 2014; Accepted: October 21, 2014; Published: October 23, 2014
Citation: Freitas LG, Paiva RAA, Callou TMP, Araújo DAC, Neto CAF, et al. (2014) Efficacy of Sublingual Use of Ketorolac Tromethamine in Reducing Pain During Treatment with Laser Photocoagulation in Patients with Diabetic Retinopathy Double Blind, Randomized, Sham-Controlled Study. J Clin Exp Ophthalmol 5:364. doi:10.4172/2155-9570.1000364
Copyright: © 2014 Freitas LG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Objective: To evaluate the analgesic effect of sublingual ketorolac tromethamine during argon laser photocoagulation in patients with diabetic retinopathy. Methods: A double blind, randomized, sham - controlled study, was conducted in 60 patients with diabetic retinopathy, referred for argon laser panretinal photocoagulation (PRP). For the evaluation of pain intensity, a numerical scale from zero to ten was used. The trial sample was divided into two groups. Group 1 consisted of 27 patients who used one 10 mg tablet of ketorolac tromethamine and group 2 comprised of 33 patients who used a sham, both with the same method of administration, 30 minutes before application of the laser. Results: Of the 27 patients in Group 1, 20 (74%) felt pain in the first stage, 5 (19%) experienced pain in the second stage and 2 (7%) felt no pain at any time. Of the 33 patients in Group 2, 27 (82%) felt pain in the first stage, 3 (9%) experienced pain in the second stage and 3 (9%) felt no pain at any time. There was no statistically significant difference between the groups (p=0.65 and 0.33). Conclusion: Ketorolac tromethamine was not able to reduce pain during panretinal photocoagulation in patients with proliferative diabetic retinopathy.

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