Electrical Stimulation of the Nucleus Accumbens Shell Reduces Voluntary Ethanol Consumption in Bulbectomized RatsBecker A1*, Knape C1, Wetzel W2, Peters B3 and Ohl FW2,4,5
- *Corresponding Author:
- Axel Becker
Faculty of Medicine, Institute of Pharmacology and Toxicology
Otto von Guericke University, Leipziger Str. 44
39120 Magdeburg, Germany
E-mail: [email protected]
Received Date: June 01, 2015; Accepted Date: June 11, 2015; Published Date: June 16, 2015
Citation: Becker A, Knape C, Wetzel W, Peters B, Ohl FW (2015) Electrical Stimulation of the Nucleus Accumbens Shell Reduces Voluntary Ethanol Consumption in Bulbectomized Rats. J Alcohol Drug Depend 3:210. doi:10.4172/2329-6488.1000210
Copyright: © 2015 Becker A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Alcoholism is often accompanied by depression. It has been shown that deep electrical stimulation of the nucleus accumbens is effective in the treatment of alcoholism. Objective: Despite the promising results of clinical trials, the mechanisms underlying its effects are still unclear. To elucidate these mechanisms, valid animal models are needed. Methods: We investigated the effects of electrical stimulation of the nucleus accumbens shell (NAS) and nucleus accumbens core (NAC) on alcohol intake in bulbectomized rats. Bilateral removal of the olfactory bulbs (OBX) is considered a valid animal model of depression. Results: It was shown that electrical stimulation of the NAS with the described stimulus parameters significantly reduced voluntary ethanol intake in OBX rats. After the cessation of stimulation, this effect became insignificant. In contrast, stimulation of the NAC did not modify voluntary ethanol intake. In sham-bulbectomized animals, voluntary ethanol intake was negligible and ethanol consumption did not alter as a result of electrical stimulation of the NAC or NAS Conclusions: Our study underlines the relevance of the OBX model in the study of depression comorbid alcohol intake. Moreover, it might be useful in the study of the mechanisms underlying the clinical effectiveness of electrical stimulation of the NAS in the treatment of alcoholism.