Electroanalysis of Mefenamic Acid in Pharmaceutical Formulation and Spiked Biological Fluids on Modified Carbon Nanotube ElectrodeAbdolmajid Bayandori Moghaddam1, Ali Mohammadi2,3* and Somaye Mohammadi2,4
- *Corresponding Author:
- Ali Mohammadi
Department of Drug and Food Control
Faculty of Pharmacy
Tehran University of Medical Sciences
E-mail: [email protected]
Received date: June 30, 2012; Accepted date: August 27, 2012; Published date: August 29, 2012
Citation: Moghaddam AB, Mohammadi A, Mohammadi S (2012) Electroanalysis of Mefenamic Acid in Pharmaceutical Formulation and Spiked Biological Fluids on Modified Carbon Nanotube Electrode. Pharmaceut Anal Acta 3:165. doi: 10.4172/2153-2435.1000165
Copyright: © 2012 Moghaddam AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The development of an electrochemical sensor for determination of mefenamic acid is the main purpose of this work. The determination was performed in pharmaceutical formulations, spiked urine and human plasma samples by multi-walled carbon nanotube-graphite/Ag (MWCNTs-G/Ag) electrode. Hence some voltammetric methods were investigated to determination of mefenamic acid. The dependence of peak currents and potentials on pH and voltammetric parameters was investigated for the optimization of electrochemical method. The porous structure of MWCNTs-graphite mixture improves the electroactive surface area. As a result, a remarkable increasing in the peak currents was observed. The prepared mixture displayed an electrocatalytic effect in anodic oxidation of mefenamic acid with a sensitivity augmentation. The best electrochemical response was obtained from square wave voltammetry with a sensitive peak at 0.68 V in pH 5. The prepared electrode showed good standard calibration curves during 3 days over a wide concentration range with RSD values ranging from 1.6-8%. The limits of quantification and detection were 50 and 16 ng/mL, respectively.