alexa Electroclinical Features of Lennox-Gastaut Syndrome in
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Electroclinical Features of Lennox-Gastaut Syndrome in Adulthood and Adolescence

Adriana Ma Goicoechea Astencio1, René Andrade Machado1*, Yudith Merayo2, Andrés Rodrigo Solarte Mila3, Martha Jiménez Jaramillo4 and Juan Felipe Alvarez Restrepo4

1National Institute of Neurology and Neurosurgery, Epilepsy Section, Cuba

2Hospital Clínico Quirúrgico de Morón, Ciego de Ávila, Cuba

3León XIII Clinic, Antioquia University, Colombia

4Neurologic Institute of Antioquia, Colombia

Corresponding Author:
René Andrade Machado
National Institute of Neurology and Neurosurgery
Epilepsy Section, Cuba
E-mail: [email protected]

Received date: April 16, 2013; Accepted date: June 17, 2013; Published date: June 25, 2013

Citation: Astencio AMG, Machado RA, Merayo Y, Mila ARS, Jaramillo MJ, et al. (2013) Electroclinical Features of Lennox-Gastaut Syndrome in Adulthood and Adolescence. J Neurol Neurophysiol S2:008 doi:10.4172/2155-9562.S2-008

Copyright: © 2013 Astencio AMG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Introduction: Lennox- Gastaut Syndrome (LGS) is characterized by seizures which may have inconspicuous semiological features so they may be unrecognized while patients are continuously deteriorating. To confirm its clinical and electrographic characteristics is mandatory, which has therapeutic and prognostic implications. Those features have not been completely elucidated in LGS in adulthood.
Purpose: We performed a descriptive study to investigate seizure types, interictal and ictal EEG characteristics and cognitive outcome in adult LGS subjects.
Methods: We evaluated 28 cases with development impairment and several refractory seizure types, which included tonic seizures, in order to make a screening of LGS. We confirm LGS diagnosis in 24 patients older than 12 years who were assessed by video-EEG, particularly to record seizure types and EEG findings as well as cognitive outcome.
Results: During this stage of the disease, all patients presented tonic seizures (TS) during wakefulness and sleep, 12/24 had atypical absences, more rarely other seizure types. Some cases (5/24) have evolved from West syndrome and in 62.5% aetiology was cryptogenic. Interictal EEG showed normal background activity in 13/24 patients, slow spike-wave discharges during wakefulness was diffuse just in 4/24; bursts of diffuse fast rhythms (DFR) in sleep were seen in all patients. A moderate to severe cognitive impairment was observed in 18/24 patients, but all of them experience deterioration after the epilepsy had begun.
Conclusions: In adult LGS patients a standard waking EEG may be normal. TS during sleep and the presence of DFR are paramount to confirm the diagnosis.

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