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ISSN: 2155-9538

Journal of Bioengineering & Biomedical Science
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Research Article

Elevated Pressure Aqueous Hemostasis: Experimental and Mathematical Modeling

Matt T Oberdier* and James F Antaki

Department of Biomedical Engineering, Carnegie Mellon University, USA

*Corresponding Author:
Matt T Oberdier
Department of Biomedical Engineering
Carnegie Mellon University
Pittsburgh, PA 15213, USA
Tel: +412 268 9857
E-mail: [email protected]

Received Date: September 17, 2013; Accepted Date: November 04, 2013; Published Date: November 11, 2013

Citation: Oberdier MT, Antaki JF (2013) Elevated Pressure Aqueous Hemostasis: Experimental and Mathematical Modeling. J Bioeng Biomed Sci 3: 126. doi: 10.4172/2155-9538.1000126

Copyright: © 2013 Oberdier MT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Elevated Pressure Aqueous Hemostasis is defined as the use of hydrostatic pressure via an isotonic liquid medium in a closed surgical field to control bleeding. It is an effective yet under-characterized means of achieving hemostasis; however, compromised perfusion is a potential complication. Therefore, the objective of this study was to determine the optimal range of extravascular pressure that both limits hemorrhage and allows antegrade flow. A steady-state experimental flow system was employed to simulate series arterial and venous hemodynamics, venous collapse, and arterial hemorrhage. A corresponding lumped-parameter mathematical model, calibrated to experimental data, was then used to extrapolate to conditions of hypotension, normotension, hypertension, limited venous collapse, venous hemorrhage, and simultaneous arterial and venous hemorrhages. Experiments with an elastomeric phantom vessel showed that hemorrhage from a stab incision was diminished with increasing extravascular pressure but was accompanied by decreased antegrade flow due to venous collapse. Above arterial pressure, flow ceased. Hence, a preferred pressure domain for aqueous hemostasis was defined to be greater than venous pressure to reduce bleeding and at least ten mmHg below arterial pressure to allow antegrade flow. Results from the lumped-parameter model suggest that i) a tethered vein may permit more antegrade flow for a given extravascular pressure; and ii) an elevated extravascular pressure in the presence of a venous rent may cause intravasation. A set of indices of perfusion and hemorrhage were introduced to generalize these results and suggest guidelines for clinical practice.


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