alexa Elevation of Neutrophil Elastase Activity in Intra-Operative Recovered Shed Blood | OMICS International
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Review Article

Elevation of Neutrophil Elastase Activity in Intra-Operative Recovered Shed Blood

Soichi Maekawa, Kensuke Umakoshi, Satoshi Kikuchi, Hironori Matsumoto, Jun Takeba, Suguru Anen, Naoki Moriyama and Mayuki Aibiki*

Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Ehime University, Japan

*Corresponding Author:
Mayuki Aibiki
Department of Emergency and Critical Care Medicine
Graduate School of Medicine, Ehime University
Shitsukawa 454, Tohon, Ehime, 791-0295, Japan
Tel: +81-89-960-5722
Fax: +81-89-960-5714
Email: [email protected]

Received date: July 28, 2014; Accepted date: October 29, 2014; Published date: November 25, 2014

Citation: Maekawa S, Umakoshi K, Kikuchi S, Matsumoto H, Takeba J, et al. (2014) Elevation of Neutrophil Elastase Activity in Intra-Operative Recovered Shed Blood. J Blood Disord Transfus 5:235. doi: 10.4172/2155-9864.1000235

Copyright: © 2014 Maekawa S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and Aim: Neutrophil elastase releasing from activated polymorphonuclear neutrophils (PMN) may have a central role in acute lung injury. Thus, we examined whether neutrophil elastase activity (NEA), a crucial parameter for organ damages from stresses, may increase in intra-operative recovered blood and also whether the storage duration of the bank bloods may affect such changes in NEA. Methods: In thirty-two packed red cells of bank bloods, NEAs were measured by ELISA on several day points after the storage. Intra-operative salvaged red cell concentrates (RCCs) were obtained from thirteen patients undergoing spinal surgery. The salvaged bloods from the patients were divided into two groups: NE activities in autologous RCCs obtained from eight patients were examined soon after the preparation (Group A); such activities in RCCs from five subjects were determined post-operatively (Group B). Results: In the bank bloods, NEAs gradually increased after the storage, showing a plateau at the day 10 if not specifically filtered leukocytes before the preparation. In Group B, NEA levels in RCCs were significantly higher than those in Group A. In Group B (RCCs stored for four hours), NEAs were nearly two times higher than those of the peak NEA values of the bank blood at the day 21. Conclusion: Thus, we need to pay attention the occurrence of lung injury even after the transfusion of autologous bloods collecting by the intra-operative shed blood recovered system.

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