Ellagic Acid – Chemopreventive Role in Oral CancerPrakash S Bisen1*, Saurabh S Bundela1,2 and Anjana Sharma2
- *Corresponding Author:
- Professor P.S. Bisen
Defence Research Development Establishment
Defence Research Development Organisation
Ministry of Defence, Govt. of India
Jhansi Road, Gwalior 474002, India
E-mail: [email protected]
Received date: December 17, 2011; Accepted date: February 07, 2012; Published date: February 09, 2012
Citation: Bisen PS, Bundela SS, Sharma A (2012) Ellagic Acid - Chemopreventive Role in Oral Cancer. J Cancer Sci Ther 4: 023-030. doi: 10.4172/1948-5956.1000106
Copyright: © 2012 Bisen PS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ellagic acid is an antioxidant and an anti-proliferative compound present in fruits, nuts and vegetables. In spite of evidences for anticancer activity in various cancer cell-lines, human cancer cells, the mechanistic role of ellagic acid is not conclusive enough to be recommended for a clinical use. The present review provides information about the chemopreventive role of ellagic acid in oral cancer and proposes molecular basis for ellagic acid’s inhibitory activity against oral cancer. We show that ellagic acid modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway (cyclin dependent kinase 2, cyclin A2, cyclin B1, cyclin D1, c-myc, PKCα), cell survival/apoptosis pathway (Bcl-XL, Bax, Caspase 9/3, Akt), tumor suppressor pathway (p53, p21), inflaming Metastasis pathways (IL-1 beta, TNF-α, matrix metalloproteinases 9/3, COX-2), angiogenesis pathways (VEGF), cell immortalization (TERT), NF-κβ.